Under a Creative Commons license Open accessHighlights Summary PRC2 creates the repressive mark histone H3 Lys27 trimethylation. Although PRC2 is involved in various biological processes, its role in glial development remains ambiguous. Here, we show that PRC2 is required for oligodendrocyte (OL) di...
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To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Reprints and permissions About this article Cite this article Liefke, R., Shi, Y. The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells. Cell Discov 1, 15008 (2015). ...
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Under a Creative Commons license open accessHighlights Summary Control of stem cell-associated genes by Trithorax group (TrxG) and Polycomb group (PcG) proteins is frequently misregulated in cancer. In leukemia, oncogenic fusion proteins hijack the TrxG homolog KMT2A and disrupt PcG activity to ma...
Under an Elsevier user license Open archiveHighlights Summary Polycomb repressive complexes (PRCs) 1 and 2 are essential chromatin regulators of cell identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub-complexes that possess catalytic-dependent H2AK119 mono-ubiqui...
We first tested the role of Dpf2 in ESC self-renewal. Absence of Dpf2 expression led to a decrease in colony formation (Figure 1A), suggesting an impairment of self-renewal ability. The lower colony number arising from Dpf2−/− cells coincided with a small increase in apoptosis under fee...
Under an Elsevier user license Open archiveHighlights Summary Polycomb repressive complex 2 (PRC2) silences expression of developmental transcription factors in pluripotent stem cells by methylating lysine 27 on histone H3. Two mutually exclusive subcomplexes, PRC2.1 and PRC2.2, are defined by the ...
Under a Creative Commons license Open accessHighlights Summary Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 (H3K27me3) to maintain gene repression and is essential for cell differentiation. In low-grade endometrial stromal sarcoma (LG-ESS), the PRC2 subunit SUZ12 is ofte...