Lewis EB. A gene complex controlling segmentation in Drosophila. Nature. 1978;276:565–70. CAS PubMed Google Scholar Ntziachristos P, Tsirigos A, Van Vlierberghe P, Nedjic J, Trimarchi T, Flaherty MS, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lym...
Lewis EB. A gene complex controlling segmentation in Drosophila. Nature. 1978;276:565–70. CAS PubMed Google Scholar Ntziachristos P, Tsirigos A, Van Vlierberghe P, Nedjic J, Trimarchi T, Flaherty MS, et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lym...
Importantly, even a transient depletion of PRC1 core complex subunits leads to cancer formation inDrosophila(Parreno et al.2024). Specifically, a 24-h depletion of the PRC1 subunit PH results in irreversible activation of key members of the JAK–STAT pathway, which in turn trigger a switch to...
PRC2 is also required for the differentiation of numerous other cell types, including endometrial stromal cells (Grimaldi et al., 2011; Nancy et al., 2018; Osokine et al., 2022). In addition to the core PRC2 subunits, accessory factors define two PRC2 variants: PRC2.1, which contains ...