pRb-E2F signaling in life of mesenchymal stem cells: Cell cycle, cell fate, and cell differentiation. Genes & Diseases. 2014; 1:174-187.Popov B & Petrov N (2014) pRb-E2F signaling in life of mesenchymal stem cells: cell cycle, cell fate, and cell differentiation. Genes Dis 1, 174-...
Identification of Target Genes of the p16INK4A-pRB-E2F PathwayHumansTetracyclineTranscription FactorsRNADNA-Binding ProteinsRetinoblastoma ProteinCell Cycle ProteinsMicroscopy, FluorescenceProtein Synthesis InhibitorsBlotting, NorthernDeregulation of the retinoblastoma protein (pRB) pathway is a hallmark of human ...
百度试题 题目pRB蛋白属于核内磷蛋白,其以 形式与E2F结合,使后者失去功能,阻断细胞从G1期进入S期。相关知识点: 试题来源: 解析 低磷酸化型、转录因子 反馈 收藏
This, to our knowledge, is the first study showing the involvement of the pRb–E2F/DP pathway in antiproliferative and apoptotic effects of EGCG. 展开 关键词: EGCG retinoblastoma E2F cell cycle DOI: 10.1006/abbi.2001.2704 被引量: 131
Deregulation of the retinoblastoma protein (pRB) pathway is a hallmark of human cancer. The core members of this pathway include the tumor suppressor protein, pRB, which through binding to a number of cellular proteins, most notably members of the E2F transcription factor family, regulates ...
In response to ABT-737, pRb is cleaved by caspases into a p68Rb form that still interacts with E2F-1. Moreover, pRb occupies the noxa promoter together with E2F-1, in a caspase-dependent manner upon ABT-737 treatment. Thus, caspases contribute to trigger the mitochondrial apoptotic pathway...
解:A、Rb基因表达产物pRb蛋白可与调控因子E2F结合,进而抑制E2F的功能,Rb基因突变导致视网膜母细胞瘤,所以Rb基因可能是一种与癌变有关的抑癌基因,A正确;B、Rb基因是核基因,其突变产生产生的新基因是其等位基因,B正确;C、由图可知,E2F通过调控DNA聚合酶的合成促进细胞分裂,C正确;D、可通过导入正常基因治疗该疾病,...
In the present manuscript, we show that THAP1 is an endogenous physiologic regulator of EC proliferation and G1/S cell-cycle progression, which modulates expression of several pRb/E2F cell-cycle target genes. In addition, we identify RRM1, a G1/S-regulated gene required for S-phase DNA ...
A、Rb基因表达产物pRb蛋白可与调控因子E2F结合,进而抑制E2F的功能,Rb基因突变导致视网膜母细胞瘤,所以Rb基因可能是一种与癌变有关的抑癌基因,A正确; B、Rb基因突变可产生的新基因或其等位基因,B正确; C、E2F可与靶基因结合启动靶基因的表达,最终能促进细胞分裂,如图E2F通过调控DNA聚合酶的合成促进细胞分裂,C正确...
Hauck L, von Harsdorf R.: E2F transcription factors and pRb pocket proteins in cell cycle progression . Methods Mol Biol 2005; 296 : 239–245Hauck L, von Harsdorf R. E2F transcription factors and pRb pocket proteins in cell cycle progres- sion. Methods in molecular biology 2005;296:239-...