The dose range of prazosin was 1–15 mg at every bedtime (0.02–0.3 mg/kg), with 35% receiving ≥5 mg/day. Treatment-emergent side effects were reported by 26% (n= 8) of patients, including dizziness (18%), anxiety (9%) and headaches (6%). Prazosin treatment was ...
In anaesthetized normotensive rats, both QF0301B and prazosin (0.1–0.2 mg/kg iv) caused a pronounced and prolonged fall in mean arterial blood pressure accompanied by bradycardia. Neither QF0301B nor prazosin (0.2 mg/kg iv) significantly modified the cardiovascular effects of either 5-...