Dosing in low weight patients Patients (under 60 kg) had an increased exposure to active metabolite of prasugrel and an increased risk of bleeding on a 10-mg daily maintenance dose Consider lowering the maintenance dose to 5-mg in patients under 60 kg Geriatric: Below 75 years Same as adult...
the invention relates to a dosage for treating vascular disease in humans, the dosage of administration of a loading dose of from about 30 mg to 70 mg of prasugrel or a pharmaceutically acceptable salt thereof, and to administer and about 7.5 mg daily in 15 mg maintenance dose of prasugrel,...
What should I do if I miss a dose of prasugrel? If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses....
What should I do if I miss a dose of prasugrel? If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses....
Lee et al. Trials (2015) 16:409 DOI 10.1186/s13063-015-0925-5 TRIALS STUDY PROTOCOL Open Access Harmonizing Optimal Strategy for Treatment of coronary artery diseases – comparison of REDUCtion of prasugrEl dose or POLYmer TECHnology in ACS patients (HOST-REDUCE- POLYTECH-ACS RCT): study ...
The trial compared two types of patients with ACS , those with ST-segment elevation MI (STEMI) and those with non-STEMI orunstable angina; two types of antiplatelet therapy, ticagrelor and prasugrel; and two treatment strategies, an antiplatelet loading dose before or after angiography. ...
Dose modifications in specific populations or at given time-points may represent an avenue to minimize bleeding risk and therefore maximize the clinical benefit of prasugrel. Ongoing clinical studies with prasugrel will better define the safety and efficacy profiles of this agent and potentially set ...
In addition, the 5-mg dose of prasugrel--which was used in those aged 75 and over and in those weighing less than 60 kg--also appeared to be safe in this regard. Prasugrel is already approved for use during PCI in the setting of ACS, based primarily on the strength of the TRITON-...
the loading dose of Effient was administered at the time of diagnosis, although most received Effient at the time of PCI [seeClinical Studies]. For the small fraction of patients that required urgent CABG after treatment with Effient, the risk of significant bleeding was substantial. Although it...
Prasugrel is used in combination with low dose aspirin to prevent thrombosis in patients with acute coronary syndrome (ACS), including unstable angina pectoris, non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI), who are planned for treatment with percutaneo...