This project highlighted that Src and Src kinase family (SFK) members play a definitive role in breast cancer. Due to the paucity of translational studies, we investigated if SFK members are expressed in human breast tissue. Eight SFK members were present with distinct mRNA expression patterns in...
and PR status. Methods lmmunohistochemical method was used to detect AR, ER and PR expression in 173 cases of breast carcino ma, and all由ecases were grouped according to: ( 1) AR status: AR - positive subgroup and AR - negative subgroup, ( 2) ER status: En subgroup (negative for ...
Interpreting an immunohistochemistry (IHC) report for ER (estrogen receptor) and PR (progesterone receptor) is an important aspect of understanding the status of a patient's breast cancer. These two hormone receptors play a crucial role in the growth and development of breast cancer cells. The IH...
[2]Lila E, Nachtigall, MD. Sex hormone-Binding globulin and breast cancer risk. Oncology update,1999,6(2):39-45. [3]Jaxvinen TA, Pelto-Huikko M, Holli K, et al. Estrogen receptor beta is coepxessed with ER alpha and PR and asso...
totheER,PRstatus.Conclusions CombineddetectionofHER-2,MGMT,GST一 ,P—gP,TopⅡ,ERandPR canbeaguideforthetreatmentofbreast cancer and is also an important indicator of prognosis. 【Key Words】 Breast cancer; ER; PR; HER一2; MGMT; GST一丌; P—gP; ToplI ...
Taking the fingerprint network, we extracted fingerprint features from whole slide images and used them to predict ER, PR, and Her2 status from two independent breast cancer cohorts. We initially trained and validated our algorithms on images from The Cancer Genome Atlas (TCGA), with cross-...
Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype Purpose: To investigate the proportion of breast cancers arising inpatients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developin... SR Lakhani,JS Reisfilho,L Fulford,.....
We hypothesized that ER, PR and HER-2 expression status may change according to the day of surgical procedure. Methods: Patients who operated between 2005 and 2010 for breast cancer in our Hospital were analyzed retrospectively. Consecutive 462 patients who had breast conserving surgery and modified...
A substantial number of young breast cancer survivors experience bothersome menopausal symptoms. While the women who responded to our survey may represent a select group of survivors, these findings may have important implications for treatment decision making and long-term quality of life of young ...
In ER-positive (ER+) patients impaired CER was an independent marker of poor outcome for 5-year DFS (HR 2.469; CI: 1.049–5.810;=0.038) and BCSS (HR 1.946; CI: 1.054–3.596;=0.033) in multivariate analysis that included grade, lymph node, tumour size, HER2 status and PR status. The...