Mutations in the proline-rich transmembrane protein 2 (PRRT2) are associated with paroxysmal kinesigenic dyskinesia (PKD) and several other paroxysmal neurological diseases, but the PRRT2 function and pathogenic mechanisms remain largely obscure. Here we show that PRRT2 is a presynaptic protein tha...
MFS mice (n = 13), and WT mice treated with 50 mg/kg/day ISMN for 7 d (n = 20).bPlasma cGMP in untreated WT mice (Control) (n = 4) and WT mice treated with 5 mg/kg/day DetaNO for 2 d (n = 10).cRepresentative images of pVASP-S239 immunofluorescen...
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