PR-104SorafenibHepatocellular carcinomaAKR1C3Purpose PR-104 is activated by reductases under hypoxia or by aldo鈥搆eto reductase 1C3 (AKR1C3) to form cytotoxic nitrogen mustards. Hepatocellular carcinoma (HCC) displays extensive hypoxia and expresses AKR1C3. This study evaluated the safety and ...
[2]. Donya Moradi Manesh, et al. AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia. Blood. 2015 Sep 3;126(10):1193-202. [3]. McKeage MJ, et al. A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR...
A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors. Cancer Chemother. Pharmacol., 2010, 65, 791-801.Jameson MB, Rischin D, Pegram M et al (2010) A phase I trial of PR-104, a nitrogen mustard...
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TDA9886TS/V3 TL1451AQPWRQ1 TPA2000D1PWRG4 TSM104WAIPWRG4 深圳市至一电子有限公司 4年 月均发货速度: 暂无记录 广东 深圳市福田区 ¥0.13 全新原装3296Y-1-103LF 3266W-1-102LF 3296W-1-204LF 电位器芯片 订货号 TOP226Y、TP3C106M035C1600AS、TOIM3000TR1、TP0101KT1E3、TP3070VG...
1. metod: Microsoft Update Ova ispravka je dostupna putem Windows Update. Kada uključite automatsko ažuriranje, ova ispravka će se automatski preuzeti i instalirati. Više informacija o uključivanju automatskog ažuriranja potraži...
(LOT OF 6) AEG 104X125DC-016 CONTACT FALK MODEL 1030FZ 2A GEARBOX CUTLER HAMMER 100 AMP HEAVY DUTY SAFETY SWITCH DH363URK/ 3R Cutler-Hammer Contactor A50ENO 3 W/Rev.1891-1 Coil 120v GE FANUC BLOCK CAT NO IC660BBD100 / ELECT MODULE IC660EBD100C ...
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如图 5-D 所示,对 TM4 细胞使用 H2O2 干预造 模后,使用不同浓度的龟鹿二仙胶含药血清干预细 AB AR 1.0 EGFR 0.8 MAPK1 0.6 HIF1A 0.4 CAV1 0.2 DUOX2 0.0 ALOX5 GSTP1 NFE2L2 HSF1 AKR1C3 −0.2 −0.4 −0.6 −0.8 −1.0 图 3 龟鹿二仙胶治疗少弱精子症铁死亡靶点的 PPI 网络 (A...
研究发现,骨髓基质细胞(bone marrow stromal cells,BMSCs)可通过直接接触造血细胞或分泌多 种调控造血细胞生成的细胞因子,参与调节造血细 胞增殖,分化及凋亡[4].BMSCs 本身的增殖,凋亡 受到如红细胞生成素(erythropoietin,EPO),集落 形成刺激因子(colony-stimulating factor,CSF)及 IL-3,AKR1C3 等多种细胞因子的...