在蛋白质基因组学(Proteomics Genomics)框架下,蛋白质数量性状位点Protein Quantitative Trait Loci(pQTLs),是一种解释不同个体之间蛋白质表达水平差异的遗传变异。类似于基因组学中的表达量基因型(eQTLs)用于解释基因表达水平的差异,pQTLs解释了蛋白质表达水平的差异。 这些遗传变异位于基因组的不同位置,并影响蛋白质编...
Overall, we processed MR framework using proteins with significant pQTLs within each tissue on seven neurological‐related traits. Known proteinヾisease relationships were replicated. For example, plasma Siglec(CD33) increases the AD risk, consistent with a larger plasma﹑roteome MR analyses by Zheng...
In this study we have performed the first genome-wide association study of the third piece in this jigsaw – the role of DNA variation in relation to protein levels, or "pQTLs". We analysed 42 proteins measured in blood fractions from the InCHIANTI study. We identified eight cis effects ...
原名:Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies 译名:欧洲和非洲血统个体的血浆蛋白质组分析确定了顺式蛋白数量性状位点以及全蛋白质组...
Studying which CSF proteins associate with dementia risk loci could reveal intermediate molecular pathways connecting genetic variance to the development of disease.We aimed to identify protein quantitative trait loci (pQTLs) in ante‐mortem CSF in different types of dementia, including Alzheimer's ...
2b). Our analysis highlighted two factors: (1) putative causal pQTLs were enriched for protein domains that form an alpha-helix or beta-sheet structure (2.48-fold and 1.96-fold; Fisher’s exact test P = 7.6 × 10−6 and 1.3 × 10−3, respectively) and (2) they ...
the client sends an AES key wrapped with RSA to KMS. Without PQ TLS, an attacker could recover the wrapped key using the steps above, and use another quantum algorithm to break RSA and recover the plaintext AES key. After they have the plaintext key they can decrypt any ciphertext from...
Zhang, J., Dutta, D., Köttgen, A.et al.Plasma proteome analyses in individuals of European and African ancestry identifycis-pQTLs and models for proteome-wide association studies.Nat Genet54, 593–602 (2022). https://doi.org/10.1038/s41588-022-01051-w ...
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