The topology of the triple-helix bundle is similar yet distinct to that of the basic building block of animal and plant major facilitator superfamily (MFS) transporters (for example, GLUTs and SUTs). This finding indicates two possibilities: that SWEETs and MFS transporters evolved from an ...
This family belongs to a superfamily of transporters (the MtN3 clan in the Pfam database) which includes the 7-TM SWEET family sugar export proteins (including MtN3)7 and also 3-TM proteins such as the bacterial semiSWEETs and the mitochondrial pyruvate (MCP) transporters8,9. Recently, the...