M. tuberculosis encodes two PPX-GppA homologues, Rv0496 (MTB-PPX1) and Rv1026, which share significant sequence similarity with bacterial exopolyphosphatase (PPX) and guanosine pentaphosphate 59-phosphohydrolase (GPP) proteins. Here we delineate the respective biochemical activities of the Rv0496 ...
pppGpp alarmones inhibit the ATPase activities of Rv1026 and, to a lesser extent, the ATPase activities of Rv0496. We conclude that PPX-GppA family proteins may not possess all the catalytic activities implied by their name and may play distinct biochemical roles involved in polyphosphate and ...
问:你好,每天大便三次,每天中午吃完马上就上厕所、请问正常吗(男,28岁) 答:如果只是三次,况且大便成形,比较规律的话是正常的。大便不成形的话就考虑有结肠炎了,偶尔的不算数,考虑是正常的。放心好了。
Sharing a similar domain structure, GppA is indistinguishable from exopolyphosphatase (PPX), which mediates the metabolism of cellular inorganic polyphosphate. Here, our phylogenetic analysis of PPX/GppA homologs in bacteria shows a wide distribution with several distinct subfamilies, and our structural...
GPPApoly-Pstress responseThe inorganic polyphosphate (poly-P) is a key regulator of stress responses and virulence in many bacterial pathogens including Campylobacter jejuni. The role of exopolyphosphatases/guanosine pentaphosphate (pppGpp) phosphohydrolases (PPX/GPPA) in poly-P homeostasis and C. ...
《病原菌中PPX-GppA蛋白酶的结构与作用机理》是依托南开大学，由Mark Bartlam担任项目负责人的面上项目。中文摘要 多聚磷酸（poly-P）在细菌中具有重要的生理功能。Poly-P的水解主要由聚磷酸水解酶蛋白家族（PPX-GppA）完成。PPX-GppA对病原菌的生物膜形成能力、致病性、耐药性等方面起到重要作用。迄今对病原菌...