此外,作者在circPPP1R12A高表达的HCT-116和LoVo细胞中也进行了上述实验,结果表明过表达circPPP1R12A能加速细胞增殖,但不会加速细胞迁移和侵袭。 · 沉默circPPP1R12A会抑制结直肠癌细胞的增殖、迁移和侵袭 作者通过siRNAs沉默了circPPP1R12A,与预期一致,沉默circPPP1R12A会影响HCT-116和LoVo细胞的增殖和克隆形成...
Cohort data available from the Cancer Genome Atlas showed that high expression of PPP1R12A, PP1B encoding the catalytic subunit of the myosin phosphatase complex, or ATP8A1 correlated with poor prognosis in breast cancer patients. These results suggest that the "ATP8A1-PS-YAP phosphatase" axis...
Know comprehensive PPP1R12A protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.
Ppp1r12a 基因标记细胞类型举例 肾脏系膜细胞 人类同源基因 PPP1R12A 人类同源基因关联疾病 智力低下、性发育障碍品系描述 在Ppp1r12a基因目的exons两侧分别插入loxP位点。该flox小鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Ppp1r12a基因的小鼠模型。 *使用本品系发表的文献需注明: Ppp1...
PPP1R12A 导读 基因简介 中英文全称:蛋白磷酸酶1, 调控(抑制因子)亚基12A protein phosphatase 1, regulatory (inhibitor) subunit 12A 分布:肌 动蛋白细胞骨架 活性:信号转导因子 参与:调控肌收缩 OMIM/位置:602021 12q15-q21
L29803PPP1R12A基因敲除HEK293T细胞RIPA裂解液100µg1258.00元 L29804PPP1R12A基因敲除HEK293T细胞Trizol裂解液500µl1258.00元 PPP1R12A Knockout HEK293T Cells (PPP1R12A基因敲除HEK293T细胞)是通过同时表达Cas9、目的基因sgRNA和puromycin抗性基因,并实现了目的基因CRISPR敲除的HEK293T细胞。本细胞中目的基因...
3、circPPP1R12A促进细胞增殖 在两个低circPPP1R12A表达的CC细胞系(DLD-1和Caco-2)中通过质粒过表达了circPPP1R12A,并通过PCR验证过表达效率。CCK8和集落形成的结果表明,circPPP1R12A过表达加速了DLD-1和Caco-2细胞的细胞增殖。划痕实验和Transwell结果表明,过表达circPPP1R12A也增强DLD-1和Caco-2细胞的迁移...
基因名称: PPP1R12A 基因又名: GUBS; M130; MBS; MYPT1 Gene ID: 4659 种属 Homo sapiens DNA序列编号: NM_002480.3 DNA描述 Homo sapiens protein phosphatase 1 regulatory subunit 12A (PPP1R12A), transcript variant 1, mRNA DNA大小: 5620 bp DNA编码区: atgaagatggcggacgcgaagcagaagcggaacgagcagctga...
碧云天网站 微信公众号 碧云天生物技术/Beyotime Biotechnology 订货热线: 400-1683301或800-8283301 订货e-mail: order@beyotime.com 技术咨询: info@beyotime.com 网址: http://www.beyotime.com PPP1R12A Knockout HEK293T RIPA Lysate 产品编号 L29803 产品名称 PPP1R12A Knockout HEK293T RIPA Lysate 包装 ...
Knockdown experiments of these phosphatases suggested that PPP1R12A, a regulatory subunit of the myosin phosphatase complex, was essential for YAP-dependent proliferation of triple-negative breast cancer MDA-MB-231 cells. Knockdown of PPP1R12A increased the level of phosphorylated YAP, reduced that ...