PDP1 and PDP2 are mitochondrial matrix serine phosphatases, which function in the regulation of the mammalian pyruvate dehydrogenase complex (PDC or PDHc). PDHc consists of three components (E1, E2, and E3) and catalyzes the irreversible aerobic decarboxylation of pyruvate to form acetyl-CoA, ther...
PPM1A and PPM1B associate with the phosphorylated form of IKKβ, and the interaction between PPM1A/PPM1B and IKKβ is induced by TNFα in a transient fashion in the cells. Furthermore, knockdown of PPM1A and PPM1B expression enhances TNFα-induced IKKβ phosphorylation, NF-κB nuclear ...
In full form, ppm is expressed as one in a million, or {eq}ppm=1/1,000,000=0.0001 {/eq}% of the whole. The concentration of a solution in a beaker can be described as ppm. PPM Definition and Units Depending on the substance being measured, 1 ppm can be expressed in different ...
infects warm-blooded animals including an estimated two billion people1,2. Infection withToxoplasmaoccurs either by consumption of undercooked or raw meat from infected animals, ingestion of environmental oocysts that are the products of sexual reproduction in cats and are expelled in their feces, or...
Protein Form: Recombinant, Full Length Purification: PAGE Protein Family: Other Proteins Molecular Weight: 43.8 kDa Research Category: Signal Transduction Protein Tag or Fusion: His Tag Validated Application: Assay Standard Regulatory Statement: For Research Use Only. Not for use in diagnos...
Full size image Introduction to current therapies Four key approaches are currently used for the treatment of CRC: surgery, chemotherapy, radiotherapy and targeted therapies. The mainstay of CRC treatment is surgery. In early stage disease (stage 0 or I), surgical excision can be used without ne...
Myc-PPM1B was made by inserting a PCR-amplified full-length cDNA of murine PPM1B (Open Biosystems) into the BamHI-EcoRI site of pCMVTag3B (Agilent Technologies). Primers used to amplify DNA sequences are listed in Table 1. The phosphatase-defective PPM1B mutant (ΔPPM1B) was ...