Consistent with the Robertson subtype distribution, 65% of patients were luminal and 35% were non-luminal (basal-squamous and neuronal); 10 of 13 luminal patients had one or more genetic alteration in PPARG, RXRA and/or FGFR3. High PPARG expression was associated with luminal subtype compared ...
Peroxisome proliferator-activated receptor-γ (Pparg) is a nuclear hormone receptor that regulates numerous cellular functions, including adipogenesis, lipid biosynthesis, energy expenditure and storage, inflammation, and differentiation7.Ppargacts in a number of tissues and cell types, including liver, adi...
(突变、扩增或过表达)或由RXRA激活突变导致的PPARG功能的激活状态。在一些方面,本文 公开的化合物和药学上可接受的盐将抑制状态(NCOR1募集)增加至比先前公开的PPARG调 节剂(如现有的反向激动剂)更高的程度。这样的结果甚至出现在突变环境中。参见例如实 施例部分中定性评估HT1197中NCOR1募集和PPARG靶基因抑制的表格...
Position weight matrix (PWM) for mouse PPARG::RXRA binding site was run with relative profile score threshold set at 80%. 2.12. ChIP assay Chromatin Immunoprecipitation (ChIP) assay to detect PPARG binding to selected PPRE sequences was performed on osteocyte like MLO-Y4 cells (kind gift from...
饱和长链脂肪酸(C16和C18)比ROSI的效应更强,能够明显上调大部分检测的基因,而CLA却极大的下调了FASN,FADS1,LPIN1,SREBF1,SREBF2,INSIG1,RXRA,NCOR1和FABP3基因的表达(P0.05).同时研究发现,GW和饱和脂肪酸共同处理细胞没有完全消除饱和脂肪酸对...
M. et al. Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation. Elife 6, e30862 (2017). Sugii, S. et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc. Natl Acad. Sci. USA ...
9,10 Approximately 40% of MIBC tumors exhibit high PPARγ activity, which results from activating mutations in RXRA, copy number amplification of PPARG, or increased PPARG gene expression.16,26 Of these mechanisms, upregulation of PPARG mRNA levels is the most common, with 27% of MIBC tumors...
However, more than half of the PPARG-activated bladder tumors and cell lines do not have identifiable somatic alterations in either PPARG or RXRA. Using a PPARG-driven reporter assay in RT112 bladder cancer cell line, we screened probe compounds to identify candidate drivers of ligand-independent...
Mechanistic Insights into How a Model Obesogen, Tributyltin (TBT), Affects Peroxisome Proliferator Activator Gamma (PPARg) and Retinoid X Receptor Alpha (RXRa) Coregulator Complexes on Target GenesLindsey S. Treviño
Choi, J. S.Choi, S. S.Kim, E. S.Seo, Y. K.Seo, J. K.Kim, E. K.Suh, P. G.Choi, J. H.CELLULAR SIGNALLINGChoi JS, Choi SS, Kim ES, Seo YK, Seo JK, Kim EK, et al. Flightless-1, a novel transcriptional modulator of PPARg through competing with RXRa. Cell Signal 2015...