………・ 49 PPARy、NF—KB信号 作目的:动物实验发现,预先给予短时、轻微、不至于引起神经元损伤 的脑缺血,可以保护神经元,使其能够耐受其后通常会引起神经元损伤的 较严重的脑缺血,这一现象被称为脑缺血耐受,预先给予的短时、轻微、 不至于引起神经元损伤的脑缺血称为脑缺血预处理。自1990年Kitagawa 首先提出...
子痫前期胎盘组织中PPAR八NF.rB的表达及意义 中文摘要 目的:通过检测子痫前期患者胎盘组织中过氧化物酶体增殖物激活受体 7(PPARz)和核因子K B fNF-茁B)的表达变化,分析二者可能存在的关系,为探 讨子痫前期的发病机制提供线索。 方法:采用免疫组织化学二步法检测20例正常孕妇(对照组)和45例子痫 前期患者(其中轻度...
Nuclear factor kappa B (NF- κB) is a nuclear transcriptional activator that plays a central role in the stress response and inflammation, and is activated by pathogenic stimuli.[5] In this study, we examined the therapeutic effects of Dan-shao-hua- xian and the expression of PPAR-γ and ...
Glucagon like peptide-1 (GLP-1) modulates OVA-Induced airway inflammation and mucus secretion involving a protein kinase a (PKA)-Dependent nuclear factor-kappa B (NF-kappa B) signaling pathway in mice[J]. Int J Mol Sci, 2015, 16(9): 20195-211. [18]Zhu T, Li CY, Zhang XE, et al...
NF-κB 还作为多条通路的重要下游蛋白参与通路的激活,在氧化应激、免疫炎症以及细胞凋亡中起着重要作用,与RA 的严重程度密切相关。NF-κB p65是NF-κB 亚基中最关键的亚基,其经典激活途径为在体内由外界刺激或炎症反应等激活后,催化多种亚基和调节亚基形成多亚基激酶(inhibitor of nuclear factor kappa-B kinase,...
子痫前期胎盘组织中PPAR八NF.rB的表达及意义 中文摘要 目的:通过检测子痫前期患者胎盘组织中过氧化物酶体增殖物激活受体 B 7(PPARz)和核因子KfNF-茁B)的表达变化,分析二者可能存在的关系,为探 讨子痫前期的发病机制提供线索。 方法:采用免疫组织化学二步法检测20例正常孕妇(对照组)和45例子痫 前期患者(其中轻度...
目的:探讨眼局部应用过氧化物酶体增殖物激活受体(peroxisomeproliferator- activated receptor gamma,PPAR-γ)激动剂吡格列酮(Pioglitazone)对大鼠角膜碱烧伤后核转录因子-kappaB(nuclear factor-kappa B,NF-κB)和肿瘤坏死因子-alpha(tumor necrosis factor-alpha,TNF-α)表达的影响. 方法:48只健康SPF级SD大鼠角膜碱烧...
Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation NF-kappaB and STATs regulate multiple cellular processes through the transcriptional activation of genes with diversified functions. Although the molecular mechanisms that can turn on...
NF-KAPPA-B MURINE MODEL ALLERGIC INFLAMMATION GENE-EXPRESSION ROSIGLITAZONE ALPHA AGONISTS 摘要 Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and chronic obstructive pulmonary disease. AMH contributes ...
(aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity). (Microbial infection) ...