The combination may also apply to localized disease to reduce adverse side effects of intensive cytotoxic chemotherapy. Citation Format: Xiang Nan, Jiang Wang, Jianting Sheng, Ching C. Lau, Jason T. Yustein, Hong Zhao, Stephen Wong. Imatinib revives the therapeutics potential of metformin in ...
but a number of mechanisms still need to be further elucidated as a basis for the individualized use of metformin and multimorbidity combination therapy [18,19]. Therefore, the present
Hyperpigmentation disorders are generally difficult to treat because of the limited availability of effective therapeutics with minimal side effects. In this issue, Lehraiki et al. report that metformin, an antidiabetic drug, inhibited melanogenesis, in vitro and in vivo, and they suggest that ...
et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642–1646 (2005). CAS PubMed PubMed Central Google Scholar Owen, M. R., Doran, E. & Halestrap, A. P. Evidence that metformin exerts its anti-diabetic effects through ...
cardiovascular disease‐related gene sets, positive correlation with hypertension‐related transcriptomic signatures and the associations of drugs with hypertensive side effect together indicate that although metformin does exert various beneficial effects, it would also increase the risk of hypertension in ...
some studies have already demonstrated the feasibility of mitochondrial-targeted treatment for DKD. It has been reported that metformin can mitigate renal oxidative stress and tubulointerstitial fibrosis in DKD mice by enhancing the level of mitophagy through Pink1/Parkin pathway (Han et al.2021). Ipra...
The adverse effects of long-acting sulfonylureas can be intensified in older adults with hepatic and renal insufficiency and those with poor oral intake [56]. To mitigate risks associated with long-acting sulfonylureas, use of metformin, as first-line therapy, for older adults with type 2 ...
not been explained fully, it is useful for the metabolic reprogramming of cancer cells [109]. Metformin promoted growth arrest in pancreatic tumor cells via direct impairment of fatty acid synthesis [110]. The antitumor effects of metformin appear to be correlated with microRNA (miRNA) modulation...
Nevertheless, more studies are still needed to establish its effective therapeutic dose in humans and assess potential side effects of high doses of metformin before its application in overdose patients. 4. Caveats of testing antioxidants in preclinical models Research into natural products isolated ...
It can be noted that black seed oil has been used at doses of between 40−80 mg/kg/day as adjunctive therapy without any side effects. On the other hand, Zn intake above its recommended daily allowance (RDA) might be harmful which varies according to age, sex and other health ...