Research performed at Los Alamos National Laboratory was carried out under the auspices of the National Nuclear Security Administration of the US Department of Energy. V.M. is supported by a grant from AIRC (Italian Association for Cancer Research). J.M.L. is supported by grants from the ...
nucleotide and nucleoside receptors, ATP release channels, and nucleoside transporters. Because of its immunomodulatory function, this system is critically involved in the pathogenesis of multiple sclerosis (MS) and its best-characterized animal model, experimental autoimmune encephalomyelitis...
MAP mean arterial pressure MCP-1 monocyte chemoattractant protein-1 MR mineralocorticoid receptor MSH6 mismatch repair protein MDA malondialdehyde NAD nicotinamide adenine dinucleotide NF-κB nuclear factor kappa B NO nitric oxide NOX nicotinamide adenine dinucleotide phosphate oxidase Nrf2 nuclear factor erythr...
The study of two barley Type I-like MADS-boxgenes as potential targets of epigenetic regulation during seed development Aliki Kapazoglou, Cawas Engineer, Vicky Drosou, Chrysanthi Kalloniati, Eleni Tani, Aphrodite Tsaballa, Evangelia D Kouri, Ioannis Ganopoulos, Emmanouil Flemetakis &...
Furthermore, we identified 23 potential targets (e.g. ADORA3, which is involved in the regulation of cellular reprogramming and the extracellular matrix) and 46 candidate drugs (e.g. felbamate, methylphenobarbital and memantine) that may have value for the treatment of AIS....
AIF nuclear translocation due to overactivation of PARP leads to large-scale DNA fragmentation and chro- matin condensation, which leads to cell death and cell cycle arrest [27, 28]. This may be the related regulatory mechanism through which INSL5 affects progression of colorectal cancer, further...
Age-associated clinically actionable targets are summarized (Wilcoxon rank-sum test, FDR < 0.05, and p < 0.05 for linear regression). The TNM stage, lesion location, sex, and age of patients are annotated above the heatmap. The heatmap depicts the adjusted intensities of functional proteins wi...
nuclear matrix protein; PARP: poly(adenosine diphosphate-ribosyl)polymerase; P-gp: P-glycoprotein; RECK: reversion-inducing cysteine-rich protein with Kazal motifs; ROS: reactive oxygen species; siRNA: small-interfering RNA; STAT3: signal transducer and activator of transcription 3; Tcf: T-cell fac...
Nuclear genome size was estimated essentially as described by Doležel et al.60 using a CyFlow Space flow cytometer (Sysmex Partec) equipped with a 532-nm green laser. The gain of the instrument was adjusted so that the peak representing interphase first growth (G1) nuclei of the standard ...
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates map kinase in vivo. Cell 1993; 3: 487–93. 181 Wu JJ, Zhang L, Bennett AM. The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting ...