nucleotide and nucleoside receptors, ATP release channels, and nucleoside transporters. Because of its immunomodulatory function, this system is critically involved in the pathogenesis of multiple sclerosis (MS) and its best-characterized animal model, experimental autoimmune encephalomyelitis...
The nuclear lamina is an array of intermediate filament proteins inside the nucleus of eukaryotic cells, which supports the structure of the nucleus, including its shape and mechanical stability [1,2]. In addition, it serves as a scaffold for the attachment of DNA–protein complexes that regulate...
In the absence of any stimulus, MAP3K8 belongs to a ternary complex, comprising the nuclear factor-kB subunit precursor NF-kB1/p105, and the A20-binding inhibitor of NF-kB2 (ABIN-2), which inhibits its kinase activity19–22. Upon stimulation, MAP3K8 is released from this complex and ...
17,18. Thus, targeting MAP2K1 in tumors has been proposed as a potential therapeutic strategy to overcome acquired resistance in colorectal cancer19.
The study of two barley Type I-like MADS-boxgenes as potential targets of epigenetic regulation during seed development Aliki Kapazoglou, Cawas Engineer, Vicky Drosou, Chrysanthi Kalloniati, Eleni Tani, Aphrodite Tsaballa, Evangelia D Kouri, Ioannis Ganopoulos, Emmanouil Flemetakis &...
Fig. 4. Heatmap of the differentially expressed miRNAs obtained by sequencing in phycocyanin-treated and control A549 cells. CG, control groups; PG, phycocyanin-treated groups. Later, we subdivided the differentially expressed miRNAs into high-abundance (TPM > 100) and low-abundance (TPM < 100)...
The study of two barley Type I-like MADS-boxgenes as potential targets of epigenetic regulation during seed development Aliki Kapazoglou, Cawas Engineer, Vicky Drosou, Chrysanthi Kalloniati, Eleni Tani, Aphrodite Tsaballa, Evangelia D Kouri, Ioannis Ganopoulos, Emmanouil Flemetakis &...
IgA nephropathy (IgAN) has become the leading cause of end-stage renal disease in young adults. Nevertheless, the current diagnosis exclusively relies on invasive renal biopsy, and specific treatment is deficient. Thus, our study aims to identify potenti
(APCs) can engulf tumor cells, and tumor-cell-derived DNA activates APCs through the cGAS-STING pathway. Moreover, self-DNA from the host cell also accumulates in the cytoplasm and activates cGAS, under conditions of cellular stress or damage when nuclear or mitochondrial DNA is mislocalized ...
Further, heatmap analysis was visualized with the Heatmapper web application18. A total of 20 DEGs were identified, which consisted of 19 upregulated genes and 1 downregulated gene. External validation of the identified DEGs mRNA expression level...