SPERMINE OXIDATION AND EPIGENETIC REGULATION: IMPLICATIONS FOR INFLAMMATION/INFECTION-ASSOCIATED CARCINOGENESIS Chronic inflammation contributes to the development of various forms of cancer. The polyamine catabolic enzyme spermine oxidase (SMOX) is induced in chronic inflammatory conditions such as Helicobacter ...
The role of epigenetic alterations in pancreatic cancer this review, we briefly summarize recent research findings in the field of pancreatic cancer epigenetics and discuss their biological and clinical implications... N Sato,M Goggins - Journal of Hepato-Biliary-Pancreatic Surgery 被引量: 239发表: ...
Outline Abstract Abbreviations Keywords 1. Introduction 2. Epigenetic dysregulation in COPD 3. Epigenetic editing 4. Delivery and therapeutic potential of Epigenetic Editing 5. Future perspectives Conflict of interest statement ReferencesShow full outline Cited by (33) Figures (2)...
Perge P, Nagy Z, Decmann A, Igaz I, Igaz P. Potential relevance of microRNAs in inter-species epigenetic communication, and implications for disease pathogenesis. RNA Biol. 2017;14:391-401.Perge, P.; Nagy, Z.; Decmann, A.; Igaz, I.; Igaz, P. Potential relevance of microRNAs in...
A large number of epigenetic alterations, such as altered DNA methylation, non-coding RNA regulation, and histone modifications, are present in the preeclamptic placenta and other affected tissues, which may play an important role in the progression of the disease [52]. Among them, non-coding ...
Underneath the intricacy of every cancer lies mysterious events that impel the tumour cell and its posterity into abnormal growth and tissue invasion. Oncogenic mutations disturb the regulatory circuits responsible for the governance of versatile cellula
A common form of cell death that is also known as intrinsic or programmed cell death. Many physiological and developmental stimuli cause apoptosis, and this mechanism is frequently used to delete unwanted, superfluous or potentially harmful cells, such as those undergoing transformation. Epigenetic regu...
Validation of the genome-wide approaches was performed for SBF1 and SLC6A9 (P<.05). Conclusion(s) Methylation and transcription aberrations in individual OAT (MF) blastocysts illustrate an epigenetic consequence of MF infertility on embryogenesis, significantly altering key developmental genes and ...
progression of TC involves multiple genetic and epigenetic alterations, among which common mutations found in TC are point mutations in the BRAF and RAS genes as well as RET/PTC and PAX8/PPARγ chromosomal rearrangements [10,11]. These alterations often lead to anomalies in the proliferation, ...
COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus evolve, a complete comprehension of the disease and drug targets becomes a decisive duty. The Omicron variant, for example, has a notably high transmission rat