FRO 2014: Potential implications of epigenetic changes in human retinal pigmented epithelium during diabetic retinopathyDiabetic retinopathy (DR) is a major cause of blindness. Prevention of DR is mainly based o
et al. Challenges in infant immunity: implications for responses to infection and vaccines. Nat. Immunol. 12, 189–194 (2011). Article CAS PubMed Google Scholar Ciabattini, A. et al. Vaccination in the elderly: the challenge of immune changes with aging. Semin. Immunol. 40, 83–94 (...
A common form of cell death that is also known as intrinsic or programmed cell death. Many physiological and developmental stimuli cause apoptosis, and this mechanism is frequently used to delete unwanted, superfluous or potentially harmful cells, such as those undergoing transformation. Epigenetic regu...
Outline Abstract Abbreviations Keywords 1. Introduction 2. Epigenetic dysregulation in COPD 3. Epigenetic editing 4. Delivery and therapeutic potential of Epigenetic Editing 5. Future perspectives Conflict of interest statement ReferencesShow full outline Cited by (34) Figures (2)...
Keywords 1. Introduction 2. Methods 3. Involvement of epigenetic factors in the sequelae of CT 4. Therapies based on epigenetics 5. Discussion 6. Conclusion Declaration of Competing Interest Funding ReferencesShow full outline Cited by (42) Figures (2) Tables (3) Table 1 Table 2 Table 3Neur...
SOX2 expression and transcriptional activity identifies a subpopulation of cancer stem cells in sarcoma with prognostic implications. Cancers (Basel). 2020;12(4):964. doi: 10.3390/cancers12040964. (Open in a new window)Web of Science ®(Open in a new window)Google Scholar...
In this review, we provide a comprehensive overview on the classification, biogenesis and functions of circRNAs. We also discuss the critical role of circRNAs in eliciting antiviral immunity, providing evidence for the potential implications of circRNAs in antiviral therapies. Keywords: circular RNA, ...
Progress in dementia research has been limited, with substantial gaps in our knowledge of targets for prevention, mechanisms for disease progression, and d
Reversal of epigenetic marks may represent a novel anti-aging target. In an animal model of progeria, Zmpste24-deficient mice show hypermethylation and transcriptional silencing of rDNA genes. This effect is reversible through treatment with methyltransferase inhibitors [85]. Therefore, methyltransferase ...
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