Type 1diabetesis an autoimmune condition, where the body attacks its own insulin producing cells. It is very serious, with a sudden and dramatic onset, usually in youth. People with Type 1 diabetes must maintain an insulin-monitoring and insulin-injecting regimen for the rest of their lives. ...
type 1 diabetesinsulinstem cellscell therapyβ-cellsStem cells have been considered as a useful tool in Regenerative Medicine due to two main properties: high rate of self-renewal, and their potential to differentiate into all cell types present in the adult organism. Depending on their origin, ...
"To successfully transplant cells into humans with type 1 diabetes, you have to prevent rejection, and you have to prevent recurrence of autoimmunity," Brayman explained. "If the IgM can lower or eliminate the amount of conventional immunosuppression that needs to be used, it would be very hel...
Leeds JS, Hopper AD, Hadjivassiliou M, Tesfaye S, Sanders DS. Po- tential coeliac disease in Type 1 diabetes mellitus: does a positive antibody lead to increased complications? Nutr Metab Cardiovasc Dis. 2014;24(4):378-83. doi: 10.1016/j.numecd.2013.09.005. [PubMed: 24393392]....
However, even with intensive use of current antidiabetic agents more than 50% of T2DM patients suffer poor glycaemic control and 18% develop serious complications within six years of diagnosis. Clearly, there is a need for new antidiabetic agents. 展开 关键词: Type 2 diabetes Anti-diabetic ...
Diabetes 51, 2637–2641 (2002). CAS PubMed Google Scholar Orchard, T. J. et al. Insulin resistance-related factors, but not glycemia, predict coronary artery disease in type 1 diabetes: 10-year follow-up data from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Care 26...
Type 1 diabetes is an autoimmune disorder leading to the destruction of insulin-producing beta cells. Current clinically available methods of insulin replacement cannot prevent the occurrence of frequent hypoglycaemia and diabetic complications [1]. Hence, an insulin source that regulates glucose levels ...
Estimated incidence of cardiovascular complications related to type 2 diabetes in Mexico using the UKPDS outcome model and a population-based survey p pBackground/p pTo estimate the incidence of complications, life expectancy and diabetes related mortality in the Mexican diabetic population over the nex...
This results in the development of diabetic complications such as neuropathy, nephropathy, retinopathy and diverse cardiovascular disorders. This chapter intends to summarize thepossibilities opened by embryonic and adult stem cells in regenerative medicine for the cure of diabetes. 展开 关键词:...
Alteration of gut microbiome in type 1 and 2 DM individuals While a direct link between gut microbiota dysbiosis and T1DM development has not been confirmed, an imbalance in gut microbiota has been found at different stages of diabetes, which includes T1 and T2 DM. In patients with prediabetes...