Complications of TBI are associated with its multiple and systemic effects that should be considered in the treatment of TBI patients. Therefore, in this review, an attempt was made to examine the systemic effects of TBI in detail. It is hoped that this review will identify the mechanisms of ...
This review examines the molecular architecture and composition of various types of inflammasomes, highlighting their activation and effector mechanisms within the context of the HSCT process and its associated complications. Additionally, we summarize the therapeutic implications of targeting inflammasomes and...
Traumatic brain injury (TBI) is the leading cause of death and disability at all ages, but especially among young people. There are more than 50 million new TBI cases worldwide every year with approximately 1 million deaths. Most survivors, even from mild TBI, will have significantly increased...
The hippocampus of TBI rats demonstrated reduced neuronal death and glial activation following a solitary BDNF-eMSC treatment; repeated treatments, however, not only reduced the lingering glial activation and slowed neuronal loss, but also stimulated hippocampal neurogenesis. Furthermore, BDNF-eMSCs ...
Citation7 secondly, as we know, most of the embryonic stem cells used in the treatment are allogeneic; immunosuppressive therapy is necessary after transplantation, leading to complications. Thirdly, because of stem cells’ strong replication ability, the problem of tumorigenicity after transplantation ...
Being male and a victim of trauma is associated with increased mortality, length of hospital stay and secondary complications such as infections and multiple organ failure. This suggests that the female sex steroid hormones may have a protective effect in trauma [7, 25]. The apparent female ...
and ROS cells [86,99]. Adverse consequences and complications of ICH are associated with secondary damage and the development of neuroinflammation. Therefore, recognizing and determining the extent of the inflammatory process at an early stage is essential for optimizing immune-targeted treatment. On ...
(200 mg/kg) significantly reduced the blood glucose level, oxidative stress markers and improved dyslipidemia in diabetic rats [121]. Diabetes is associated with a number of secondary complications such as neuropathy, retinopathy, nephropathy, lower limb amputations, etc. Kuhad et al. [122] ...
We systematically address the key roles of inflammasomes in coordinating mobilization, hematopoietic reconstitution, and associated complications, with particular emphasis on acute graft-versus-host disease (aGVHD). Finally, we assess the potential benefits of targeting inflammasomes in the treatment of HSCT...
MSCs suppress T-cell prolifera- tion induced by alloantigens or mitogens via increasing the number of regulatory T cells.47,48 The interactions between T cells and MSCs have significant clinical implications in HSCT. MSCs have been shown to lessen complications of GVHD after HSCT49 and immune-...