Currently, it remains the most effective method of establishing and maintaining euglycemia over the longer term, halting and potentially reversing many of the secondary complications associated with diabetes. Significant improvements to quality of life and better life expectancy make it in the longer ...
However, a substantial subset of patients develops local complications or organ failure. Severe pancreatitis, defined by current guidelines3,4 as persistent organ failure for more than 48 hours, is associated with high mortality rates in the range of 15–20%5, partly due to limited therapeutic...
Nafamostat mesilate exhibits activity against acute pancreatitis, coagulation in blood vessels, and extracorporeal circulation.41,50, 51, 52, 53 Moreover, it acts as an antiviral agent in MERS-CoV and Influenza virus in vitro by inhibiting serine proteases that facilitate the fusion of viral membran...
Recently, emodin has been implicated as a therapeutic medicine for diabetes and its severe complications. Diabetes mellitus (DM) is a chronic disease with increasing prevalence in population growth, aging, urbanization and obesity, which complications increasingly contribute to the mortality of diabetes ...
There was no correlation between the aetiology of acute pancreatitis or the extent of necrosis and PCT or IL-8. Conclusion—PCT and IL-8 are found in high concentrations in infected necrosis and associated systemic complications in patients with acute pancreatitis. The course of PCT shows the ...
2005a). So, the effects of inflammatory mediators, cytokine storm, and oxidative stress in COVID-19 and the pathogenesis of diabetes have provided the insight that there will be a tsunami of COVID-19-induced diabetes and further complications, higher morbidity and mortality in the future (Fig...
Although the ablation of SK1 or SK2 individually does not induce substantial complications in murine models, the deletion of both enzymes results in embryonic death and disrupts key processes such as neurogenesis and angiogenesis, as observed in a developmental study [142]. Activation of SK1 in ...
Acute pancreatitis (AP) is an acute gastrointestinal disease with high mobility rate [[1], [2], [3]]. Biliary diseases, alcohol, smoking, hyperlipidemia, and heredity are the main pathogenic factors [4,5], which would lead to the sustained increase of Ca2+ in the cytoplasm of pancreatic ...
disorders and have become a popular topic of research. Research focused on inflammasomes offers a better understanding of the mechanisms of several digestive diseases and conditions, including certain bacterial and viral infections, fatty liver disease (FLD), pancreatitis, and inflammatory bowel disease ...
Treatment of streptozotocin-induced diabetic rats with alogliptin: effect on vascular and neural complications. Exp Diabetes Res. 2011;2011:Article ID 810469. 27. Monami M, Lamanna C, Desideri CM, Mannucci E. DPP-4 Inhibitors and Lipids: Systematic Review and Meta-Analysis. Adv Ther. 2012;...