Currently, it remains the most effective method of establishing and maintaining euglycemia over the longer term, halting and potentially reversing many of the secondary complications associated with diabetes. Significant improvements to quality of life and better life expectancy make it in the longer ...
However, a substantial subset of patients develops local complications or organ failure. Severe pancreatitis, defined by current guidelines3,4 as persistent organ failure for more than 48 hours, is associated with high mortality rates in the range of 15–20%5, partly due to limited therapeutic...
Nafamostat mesilate exhibits activity against acute pancreatitis, coagulation in blood vessels, and extracorporeal circulation.41,50, 51, 52, 53 Moreover, it acts as an antiviral agent in MERS-CoV and Influenza virus in vitro by inhibiting serine proteases that facilitate the fusion of viral membran...
These potential biomarkers could contribute to personalized treatment strategies to avoid severe complications and improve the outcomes of AP patients. In summary, these findings reveal potential biomarkers for diagnosing and prognosing AP, which will improve clinical decision-making in managing acute ...
Moreover, cytological analysis of the sample taken by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) may be non-precise because of sampling complications, inflammation coexistence or other conditions8. Therefore, finding possible non-invasive biomarkers at early stages of PC progression ...
The rate of SARS-CoV-2 infection in people with diabetes is similar to that of general population but post-infection complications are different and much more severe (Apicella et al.2020; Feldman et al.2020; Zhou et al.2021). Moreover, the prevalence of diabetes was 34.6% in patients wit...
Chronic pancreatitis (CP) is a specific, typically difficult to distinguish clinical disorder which develops from progressive pancreatic inflammation [1].The most common symptom of CP is severe abdominal pain which impacts seriously the quality of life of the patients [2]. Long-term complications inc...
(CAFs). This leads to the elevation of the labile iron pool to enhance the function of mitochondria and proliferation of PDAC cells [91]. Wang et al. found that the levels of S1P produced via SK1 were significantly elevated in chronic pancreatitis (CP), resulting in the activation of ...
2005a). So, the effects of inflammatory mediators, cytokine storm, and oxidative stress in COVID-19 and the pathogenesis of diabetes have provided the insight that there will be a tsunami of COVID-19-induced diabetes and further complications, higher morbidity and mortality in the future (Fig...
Initially, PSP/reg was suggested to be a marker of pancreatic injury and recurrent pancreatitis38. Serum PSP/reg is robustly increased in patients with acute or chronic pancreatitis, with some potential for false positives in patients with chronic renal failure under hemodialysis, malignancies of the...