together with the associated health problems and costs, is raising grave concern among health care professionals, policy experts, children's advocates, and parents. Patricia Anderson and Kristin Butcher document trends in children's obesity and examine the possible underlying causes of the obesity epide...
Prevalence of hyperuricemia has been increasing in both developed and developing countries1,2. High uric acid (UA) induces urate crystallization in many organs and causes gout, urolithiasis, and acute and chronic nephropathy. In addition, hyperuricemia was also associated with diseases including hyper...
Co-enzyme Q10 (Co-Q10) is an essential component of the mitochondrial electron transport chain. Most cells are sensitive to co-enzyme Q10 (Co-Q10) deficiency. This deficiency has been implicated in several clinical disorders such as heart failure, hypertension, Parkinson’s disease and obesity. ...
Obesity has the potential to reduce life expectancy by up to eight years and cut healthylife by 19 years, as a resutof diabetes(糖尿病)and cardiovascular(心血管的)disease newresearch published in the British medical journal The Lancet suggests.The study used data from the U.S. National Health...
This provides a valid test of whether an exposure causes an outcome and only depends on the three core instrumental variable assumptions11. These are: (1) the instrumental variable is associated with the exposure, (2) the instrumental variable is not associated with the factors that confound the...
Accumulating evidence has emphasized a significant association between the microbiome of the digestive system and metabolic disorders like obesity, polycystic ovary syndrome, and diabetes (Tilg, and Moschen2014; Wu et al.2021). Emerging research suggests that an imbalance in gut bacteria can impact ...
As a result of increased prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has become one of the most common causes of chronic liver disease. Although most NAFLD cases remain benign, some progress to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma....
of calcium ions causes mitochondrial calcium overload, leading to a substantial accumulation of ROS, the destruction of FLC, and FTH. These events culminate in the release of ferrous ions from the labile iron pools and the Fenton reaction, precipitating ferroptosis. Moreover, factors such as Nrf2...
-specific risk genes, many being sex-biased; the candidate molecular mechanisms converge on the nutrient-sensing capabilities of placenta and trophoblast invasiveness. These genes also implicate the Coronavirus-pathogenesis pathway and showed increased expression in placentae from a small sample of SARS-...
Insulin is an essential hormone that regulates glucose homeostasis and metabolism. Insulin resistance (IR) arises when tissues fail to respond to insulin, and it leads to serious health problems including Type 2 Diabetes (T2D). Obesity is a major contrib