相關產品 Solutions for Laboratory Weighing Automation Automate weighing in your lab for enhanced throughput and safety: powder and liquid dispensing, capsule filling, filter weighing and more. Welcome to METTLER TOLEDO — Your Global Provider of Precision Instruments and Weighing Equipment. Is this your cou...
Potent compound safetyoccupational exposure pharmaceuticalsoccupational toxicologyrisk assessmentsOccupational exposure to active pharmaceutical ingredients in a manufacturing or laboratory environmental can cause unintended health effects in workers handling these compounds. Occupational health professionals in the ...
For screening, the receptor was converted into a pdbqt file and then all ligands’ energies were minimized to convert them into a pdbqt file. The grid box was set on the amino acids of the pocket detected by the CASTp. Among all these, the compound with the highest energy was selected ...
All clinical manufacturing services are fully supported by a dedicated and experienced team of Qualified Persons, a full analytical laboratory, and a GMP-compliant warehouse. Building on 35 years in potent processing, we offer a purpose-built facility utilizing the very latest in containment technology...
Toxoplasmosis induced by Toxoplasma gondii is a well-known health threat, that prompts fatal encephalitis increased with immunocompromised patients, in addition, it can cause chorioretinitis, microcephaly, stillbirth in the fetus and even led to death. Standard therapy uses sulfadiazine and pyrimethamine ...
leading to the discovery of the first high-potency FFA2 antagonists, with the preferred compound TUG-2304 (16l) featuring IC50 values of 3–4 nM in both cAMP and GTPγS assays, favorable physicochemical and pharmacokinetic properties, and the ability to completely inhibit propionate-induced neutro...
Under laboratory conditions, Schistosoma eggs adhere to endothelial cells and induce cell migration. More than 11% of Schistosoma eggs laid in the mesenteric vessels are transported through the portal vein and stored in the liver. Inside the tissues, Schistosoma eggs secrete a variety of soluble ...
J. et al. Coding of facial expressions of pain in the laboratory mouse. Nat. Methods 7, 447–449 (2010). CAS PubMed Google Scholar Schaefer, C. F. et al. PID: the Pathway Interaction Database. Nucleic Acids Res. 37, D674–D679 (2009). CAS PubMed Google Scholar Hao, Y. et...
reduction of viral DNA, in line with clinical observations. Moreover, the toxicity profiles suggested satisfactory safety outcomes with ten times the therapeutic window. Therefore, this study provides an effective nucleic acid delivery system and a promising RNAi agent for the treatment of hepatitis B...
Through high-throughput screening (HTS), using estradiol as substrate, compound 1 was identified and selected for subsequent optimization resulting in compound 45 (BI-3231). In addition to the characterization of compound 45 for its functional, physicochemical, and drug metabolism and pharmacokinetic (...