The pivotal potassium citrate trials were non-randomized and non-placebo controlled where dietary management may have changed coincidentally with pharmacological treatment. Therefore, the results as presented in the following sections may overstate the effectiveness of the product. 14.1 Renal Tubular Acidos...
The most important aspect of the pharmacological management ofuric acid stonesis alkalinization of the urine to a range of 6.0–6.5.Potassium citrate(30–80mEqday−1) is preferable to sodiumbicarbonatebecause it avoids the sodium load. During potassium citrate therapy, the urine pH must be mon...
The demonstration of ouabain bound to the Na+–K+ pump molecular complex in its three-dimensional crystal structure [6,7] would have completed a perfect bench-to-bedside integration of molecular structure and function with one of the most classical pharmacological paradigms known. However, when ...
Thus, there is a continued need for compounds with an optimized pharmacological profile. In particular, there is a great need for selective ligands, such as SK3 channel modulators. SUMMARY OF THE INVENTION In its first aspect, the invention provides pyrimidine-2,4-diamine derivatives of Formula ...
A therapeutically effective dose refers to that amount of active ingredient which ameliorates the symptoms or condition. Therapeutic efficacy and toxicity, e.g. ED50and LD50, may be determined by standard pharmacological procedures in cell cultures or experimental animals. The dose ratio between therape...
Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo Cancer Cell, 31 (4) (2017), pp. 516-531 e510 Google Scholar Li et al., 2015 X. Li, X. Hu, X. Li, X. Hao Overexpression of tau downregulated the mRNA levels of Kv channels and improv...