The most important aspect of the pharmacological management of uric acid stones is alkalinization of the urine to a range of 6.0–6.5. Potassium citrate (30–80 mEq day− 1) is preferable to sodium bicarbonate
The pivotal potassium citrate trials were non-randomized and non-placebo controlled where dietary management may have changed coincidentally with pharmacological treatment. Therefore, the results as presented in the following sections may overstate the effectiveness of the product. 14.1 Renal Tubular Acidos...
3.1.1.3 The mitochondrial Kv1.3 represents a promising pharmacological target against cancer Following the discovery that mitoKv1.3 is a target of the pro-apoptotic protein Bax during apoptosis, membrane permeant Kv1.3 inhibitors mimicking the function of Bax have been tested in cancer cell lines expr...
Thus, there is a continued need for compounds with an optimized pharmacological profile. In particular, there is a great need for selective ligands, such as SK3 channel modulators. SUMMARY OF THE INVENTION In its first aspect, the invention provides pyrimidine-2,4-diamine derivatives of Formula ...
The demonstration of ouabain bound to the Na+–K+ pump molecular complex in its three-dimensional crystal structure [6,7] would have completed a perfect bench-to-bedside integration of molecular structure and function with one of the most classical pharmacological paradigms known. However, when ...
Pharmacological regimens for eradication of Helicobacter pylori: an overview of systematic reviews and network meta-analysis BMC Gastroenterol, 16 (2016), p. 80 View in ScopusGoogle Scholar 16 B. Hutton, G. Salanti, D.M. Caldwell, et al. The PRISMA extension statement for reporting of systemat...
Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo Cancer Cell, 31 (4) (2017), pp. 516-531 e510 Google Scholar Li et al., 2015 X. Li, X. Hu, X. Li, X. Hao Overexpression of tau downregulated the mRNA levels of Kv channels and improv...
Many voltage-gated potassium channels have been identified and characterized by their electrophysiological and pharmacological properties. Potassium currents are more diverse than sodium or calcium currents and are further involved in determining the response of a cell to external stimuli. The diversity of...
electrophysiological techniques, binding studies, pharmacological assays, and similar methodologies. The protocols for obtaining expression of ion channels in mammalian cells is well-described in the literature and known to be those skilled in the art (Choi, K. L., et al., "Tetraethylammonium ...
et al; Human ether-a-gogo related Gene (HERG) K+ channels as pharmacological targets; present and future implications.; Biochem. Pharmacol.; 1998; pp. 1741-1746; vol. 55. Tang, W. et al; “Functional expression of a vertebrate inwardly rectifying K+ channel in yeast”; Mol. Biol. ...