The pivotal potassium citrate trials were non-randomized and non-placebo controlled where dietary management may have changed coincidentally with pharmacological treatment. Therefore, the results as presented in the following sections may overstate the effectiveness of the product. 14.1 Renal Tubular Acidos...
The most important aspect of the pharmacological management ofuric acid stonesis alkalinization of the urine to a range of 6.0–6.5.Potassium citrate(30–80mEqday−1) is preferable to sodiumbicarbonatebecause it avoids the sodium load. During potassium citrate therapy, the urine pH must be mon...
3.1.1.3 The mitochondrial Kv1.3 represents a promising pharmacological target against cancer Following the discovery that mitoKv1.3 is a target of the pro-apoptotic protein Bax during apoptosis, membrane permeant Kv1.3 inhibitors mimicking the function of Bax have been tested in cancer cell lines expr...
Thus, there is a continued need for compounds with an optimized pharmacological profile. In particular, there is a great need for selective ligands, such as SK3 channel modulators. SUMMARY OF THE INVENTION In its first aspect, the invention provides pyrimidine-2,4-diamine derivatives of Formula ...
The demonstration of ouabain bound to the Na+–K+ pump molecular complex in its three-dimensional crystal structure [6,7] would have completed a perfect bench-to-bedside integration of molecular structure and function with one of the most classical pharmacological paradigms known. However, when ...
Pharmacological regimens for eradication of Helicobacter pylori: an overview of systematic reviews and network meta-analysis BMC Gastroenterol, 16 (2016), p. 80 View in ScopusGoogle Scholar 16 B. Hutton, G. Salanti, D.M. Caldwell, et al. The PRISMA extension statement for reporting of systemat...
Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo Cancer Cell, 31 (4) (2017), pp. 516-531 e510 Google Scholar Li et al., 2015 X. Li, X. Hu, X. Li, X. Hao Overexpression of tau downregulated the mRNA levels of Kv channels and improv...
Taglialatela, M. et al; Human ether-a-gogo related Gene (HERG) K+ channels as pharmacological targets; present and future implications.; Biochem. Pharmacol.; 1998; pp. 1741-1746; vol. 55. Tang, W. et al; “Functional expression of a vertebrate inwardly rectifying K+ channel in yeast”...
Pharmacological Properties Inhibitors of various potassium channels present in brain and other tissues were used to investigate the pharmacology of KCNQ2/KvLR1. The effects of 0.2 mM of 4-aminopyridine (4-AP), 10 μM E-4031, 10 μM clofilium, 0.1 mM of charybdotoxin, and 1 mM tetraethyla...
Kv1.3 channels are thought to serve as a marker of disease activity and pharmacological blockade might constitute a novel immunosuppressive strategy in UC. Present treatment regimens for UC, including corticosteroids, salicylates, and anti-TNF-α reagents, are insufficient for many patients (Hansen L....