Posttranscriptional regulation refers to the control of gene expression at the level of RNA processing, stability, and translation, which occurs after transcription of the DNA into RNA. This intricate set of processes playsa significant role in fine-tuning gene expression and ultimately shaping the ...
Considering that insulin has been reported to affect clock gene expression26,27 and its circulating levels also peaked around ZT20 (Supplementary Fig. 1e) when the oscillation of nuclear Bmal1 proteins reached the trough, we wondered whether insulin may block Bmal1 nuclear accumulation even with ...
IL-10Rα, and IL-10Rβ in cutaneous and uveal melanoma cells and specimens; ii) evaluate their post-transcriptional regulation by miRNAs; iii) ascertain whether miRNA dysregulation may affect IL-10-induced proliferation.Genome-wide miRNA expression profiling was performed using a human microarray plat...
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA. 2009;106:11667–72. Article CAS PubMed PubMed Central Google Scholar Jackson S, Xiong Y. CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem. Sci...
We demonstrated that Rpb4 and Puf3 physically, genetically, and functionally interact and also affect mRNA stability, and likely the imprinting, of a common group of mRNAs. Furthermore, the Rpb4 and Puf3 association with mRNAs depends on one another. We also demonstrated, for the first time,...
We observed that steady-state levels of proP mRNA and ProP protein are inversely correlated with cellular RNase III activity and, in turn, affect the proline uptake capacity of the cell. In vitro and in vivo analyses of proP mRNA revealed RNase III cleavage sites in a stem-loop within the...
These modifications are recognized by m6 A-binding proteins ("readers") that affect downstream functions. In plants, the scope of gene expression regulation by reader proteins is not clear. Here, overexpression and loss-of-function mutants were used to characterize the role of the Arabidopsis ...
Separate cis-trans pathways post-transcriptionally regulate murine CD154 (CD40 li- gand) expression: a novel function for CA repeats in the 3袌 untranslated region. J. Biol. Chem. 283:25606-25616.Hamilton,B.J., Wang,X.W., Collins,J., Bloch,D., Bergeron,A., Henry,B., Terry,B.M....
Gene expressionProtein abundanceDiel cycleDiurnal rhythms and light availability affect transcription–translation feedback loops that regulate the synthesis of photosynthetic proteins. The CO 2 -fixing enzyme Rubisco is the most abundant protein in the leaves of major crop species and its activity ...
Another viral protein encoded by HTLV-I, p30, has been shown to affect virus replication at the transcriptional and posttranscriptional levels. Little is currently known regarding the effect of p30 on the expression and nuclear export of cellular host mRNA transcripts. Identification of these RNA ...