It occurs between transcription and translation in eukaryotes, but does not occur in bacteria. The process involves a series of modifications that the RNA transcript (hnRNA) must undergo before it can be translated (Fig. 5.1). The second process is protein processing or post-translational ...
we found that the biogenesis and stability of these proteins are regulated both translationally, as well as post-translationally, including the efficiency of mRNA uptake into polysomes, processes that operate between translation and assembly or monitor the status (soluble and membrane-attached) of a...
Two main families of proteins, the RNA binding proteins and the RNA helicases, determine the fate of pre-mRNAs and mRNAs by regulating steps from transcription to protein translation. The RNA binding proteins bind RNA molecules immediately after the transcription, till the Protein degradation in res...
T-cell activation involves a two signal-model; APCs require a first signal from T-cell receptor (TCR), which recognizes the antigen along with the major histocompatibility complex (MHC) presented on the surface of APC. The second signal includes the co-stimulatory interaction between CD28 on the...
The post-transcriptional limitation did not appear to be due to bottlenecks in antibody assembly or secretion, suggesting that transgene mRNA translation may be limiting. The results show that TGE yields are not limited by pDNA delivery into the nuclei, but in pDNA and transgene mRNA utilization...
Two mechanisms of post-transcriptional control are implicated in organizing these processes: regulated localization of specific mRNAs by RNA-binding proteins (1), and selective mRNA translation at polyribosome hotspots (2, 3). Characterization of these mechanisms is incomplete, due not simply to their...
摘要: The primary RNA transcript of a gene is cut and spliced before translation or before assembling into ribosomal subunits or functional tRNA; it includes removal of introns, modifying (methylating,...关键词: mRNA splicing mRNA alternative splicing mRNA editing mRNA stability mRNA transport ...
BackgroundSUMOylation is an essential eukaryotic post-translation modification that, in plants, regulates numerous cellular processes, ranging from seed development to stress response. Using rice as a model crop plant, we searched for potential regulatory points that may influence the activity of the ...
cell cycle regulators and other regulatory proteins to promote tumorigenesis and cancer progression.A more thorough understanding of post-transcriptional mechanisms such as these will enable the design and development of specific therapies based on modulating the translation or stability of specific mRNAs. ...
Their structural subunits are four-transmembrane proteins named connexins (Cxs), which can be post-transcriptionally regulated by developmental and cellular signalling cues. Cx translation and mRNA stability is regulated by miRNAs and RNA-binding proteins (RBPs) such as human antigen R (HuR). In ...