It occurs between transcription and translation in eukaryotes, but does not occur in bacteria. The process involves a series of modifications that the RNA transcript (hnRNA) must undergo before it can be translated (Fig. 5.1). The second process is protein processing or post-translational ...
Birkh¨auser Boston, Cambridge, Mass.Brewer, G. 1994. Post-transcriptional considerations of gene expression: translation, mRNA stability, and poly(A) processing. In Gene Therapeutics: Methods and Applications of Direct Gene Transfer. J. A. Wolf, ed. Birkhauser, Boston, MA. pp. 40 -59....
Two main families of proteins, the RNA binding proteins and the RNA helicases, determine the fate of pre-mRNAs and mRNAs by regulating steps from transcription to protein translation. The RNA binding proteins bind RNA molecules immediately after the transcription, till the Protein degradation in res...
Jacobs John JMR,Litiere K,Van Dijk V,et al.Post-transcriptional β- 1, 3 - glucanase gene silencing involves increased transcript turnover that is translation- independent. Plant Journal The . 1997Jacobs John JMR ,Litiere K,Van Dijk V ,et al. Post - transcrip2 tionalβ - 1 , 3 - ...
Disrupted ribosomes may also preclude the translation of proteins involved in DNA damage control [11,12]. In one scenario, this could lead to the shortening of telomeres, stimulating cell death, and preventing the accumulation of mutations. On the other hand, overactivation of telomerase is ...
By targeting dozens or even hundreds of different mRNAs, individual miRNAs have the potential to fine-tune or modulate the expression of genes that participate in a specific metabolic or developmental pathway; but they can also act as reversible switches to turn on and off mRNA translation. miRNAs...
Transcription and translation are not directly coupled in eukaryotic cells, but intervening steps between them help to coordinate protein biosynthesis. RNA-binding proteins (RBPs) co-regulate functionally related mRNAs in ribonucleoprotein (RNP) modules at the steps of splicing, export, stability, locali...
3) post-transcriptional translation 转录后转译 4) split[英][splɪt] [美][splɪt] 劈裂 1. Based on the characteristics in the strength of coal seam under the action of the ground pressure, the impact coal cutting is achieved in the coal winning technique by using the impact cutting ...
ZmBH的转录后加工导致序列发生移码而提前终止,而ZmWD则缺失了大部分结构域序列,经由这种方式产生的转录后加工产物可影响蛋白编码,因而可能是对这两个基因功能进行调控的一种方式。更多例句>> 2) post-transcriptional translation 转录后转译3) Transporter associated with antigen processing,TAP 抗原加工相关转录子(...
The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While no HuR mutations have been found in cancer, a link between HuR and malignant transformation has been suggested in cancers of the breast, colon, lung, and ovary. We describe a paradigm consistent with a ...