Competition between target sites of regula- tors shapes post-transcriptional gene regulation. Nat Rev Genet 2015;16:113-26.Jens M, Rajewsky N. 2015. Competition between target sites of regulators shapes post-tr
Cancer Gene Therapy volume 30, pages 529–547 (2023)Cite this article 4316 Accesses Metrics details Abstract Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological ...
In theory, the depletion and enrichment of miRNAs during a stage transition should attenuate and enhance, respectively, post-transcriptional suppression of target genes. Therefore, we sought to identify genes that are subject to significant post-transcriptional (PT) regulation during each stage transition...
The glucocorticoid receptor (GR) has been reported to form a complex with LSD1, modulating its demethylase activity [52]. In GR-mediated transcriptional regulation, LSD1 selectively and actively removes methylation from H3K4me2 but not H3K4me1. The observation that LSD1 remains monomethylated at ...
regulation is TAK1. Through screening of natural products and testing of kinase inhibitors, Gonget al.71identified TAK1 as a kinase that promotes NLRP3 inflammasome activation in a manner independent of its role in the activation of gene expression. It was suggested that TAK1 may regulate the ...
we observed that in contrast to targets of the same TF, targets of the same sRNA rarely show a similar coexpression behavior, indicating that the level of posttranscriptional regulation has been evolved towards an additional layer of regulation that is largely involved in finetuning gene-specific ...
Cluster two was associated with a higher age of death and longer disease duration, accompanied by a decrease in transcriptional age acceleration. There are several plausible explanations as to why this trend was observed; the first is that more people assigned to this cluster may have had a ...
Regardless of the mechanism by which the negative arm imparts post-transcriptional regulation, FRQ, dPER, and hPER have extensive interactomes, with functions that range across diverse gene ontologies (Figure 4). This aligns with the large and variable interactomes that are a hallmark of negative...
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 2012; 287: 36617–36622. 46 Py BF, Kim M-S, Vakifahmetoglu-Norberg H, Yuan J. Deubiquitina- tion of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell 2013; 49: 331–338....
Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins, which control a protein’s stability. These regions, called degrons, are often controlled by PTMs, which act as signals to e