11 During acute ischemic injury, accumulation of intracellular calcium and sodium may result in depolarization of the transmembrane potential and other calcium-mediated effects. These local ionic shifts may lower the seizure threshold.2,12 Glutamate excitotoxicity is a well-established mechanism of cell ...
greater than or equal to grade 3 were as follows: 22% and 1% in cycle 1 and 1% and 0% in cycle 2 for cytokine release syndrome, 11% and 2% in cycle 1 and 8% and 2% in cycle 2 for encephalopathy, and 4% and 1% in cycle 1 and 1% and 0% in cycle 2 for seizure (Table 3...
Moreover, a multiple linear regression analysis was performed to determine the interaction between the demographic and clinical variables (age, education, type of epilepsy, duration and age at onset of epilepsy, seizure frequency, number of AEDs) and the EPDS scores, used as a dependent variable....
TPM, an anti-seizure drug, has shown efficacy in migraine prophylaxis, however, the mechanism of this effect is unclear. We studied the effect of GTN infusion on DBF in migraineurs before and after an 8-week course of TPM.Methods... A Amer,D Wack,A Supala,... - 《Clinical Pharmacolog...
Seizure duration had no effect on PIC duration except for grand mal attacks whose postictal effects were predictably longer. Our data suggest that (1) lateralisation of PIC can reliably indicate side of seizure origin, (2) duration of brain recovery after a seizure correlates better with the ...
Seizure Vasospasm (aneurysm coiling) Arterial dissection Inguinal haematoma Retroperitoneal haematoma Leg ischaemia Femoral pseudoaneurysm a Length of time in recovery will depend on the patient condition and the specific operation.CSF, cerebrospinal fluid; HDU, high-dependency unit; PACU, post-anaesthesia ...
To mitigate the effects of BBB disruption, studies have looked at various therapeutic interventions. One study investigated the impact of administering the antiseizure drug retigabine (a modulator of KCNQ2-5 neuronal potassium channels) to mice after controlled closed cortical impact. The researchers ...
While strong scientific evidence for early seizure prevention in TBI is available for phenytoin (PHT), other antiepileptic medications, eg, levetiracetam (LEV), are also being utilized in clinical settings. The use of PHT has its drawbacks, including cognitive side effects and effects on function ...
17., 34. Potential benefits of deeper cooling include a decrease in metabolic demand, decreased intracranial pressure, and suppression of seizure activity.51., 52., 53., 54. In one study of 355 patients randomized to either 24 or 48 hours of therapeutic hypothermia, survival in the 48‐...
Neutrophil adhesion that may accumulate during chronic seizures could exacerbate the prolonged hypoperfusion and other seizure-related damaging effects. Additionally, ICAM-1 is not only expressed in endothelial cells but also in microglia and astrocyte in pathological states in the brain.73 The increased...