虽然常规功能试验在冠状动脉疾病患者中很常见,但不推荐这种做法。结合ISCHEMIA研究来看,尽管两项试验中患者的特征完全不同,但更具侵入性的治疗方法(ISCHEMIA)以及更积极的随访方法(POST-PCI)并不能提供超出基于指南指导的药物治疗保守策略的额外获益。ISCHEMIA和POST-PCI试验均显示了“less is more”概念的益处。 专家简...
Despite the clinical importance of cardiomyocyte death following ischemia and reperfusion, little is known about the nature of the process. In primary rat neonatal cardiomyocyte cultures, cell death was induced by ischemia (deprivation of oxygen, serum and glucose) and reperfusion. We report here that...
Effects of ischemic pre- and postconditioning on HIF-1α, VEGF and TGF-β expression after warm ischemia and reperfusion in the rat liver BACKGROUND: Ischemic pre- and postconditioning protects the liver against ischemia/reperfusion injuries. The aim of the present study was to examine how is.....
Ischemia and post-ischemic regeneration of the small intestinal mucosa. A light microscopic and autoradiographic study. Virchows Arch [Cell Pathol] 1979; 31:259-76.Gabbert, H., R. Wagner, P. Aust, and P. Hohn. Ischemia and post-ischemic regeneration of the small intestinal mucosa. An ...
BACKGROUND AND PURPOSE: A rapid but transient expression of c-fos after cerebral ischemia has been extensively documented. However, the mechanism of this induction and whether induction of c-fos is neuroprotective or detrimental to the brain after ischemia is presently not clear. Fasting before tran...
Taiki Fukumoto1, Mamoru Ohkita1, Naoto Yamashita1, Ayman Geddawy2, Takeshi Imamura2, Kazuhide Ayajiki2, Tomio Okamura2 and Yasuo Matsumura1 Endothelin-1 (ET-1) is involved in norepinephrine (NE) overflow and cardiac dysfunction after myocardial ischemia/reperfusion via the activation of ETA rece...
Ischemic preconditioning (IP) refers to a phenomenon whereby short periods of ischemia reduce tissue damage after a subsequent sustained ischemia. The effect of IP before tourniquet ischemia of the extremities has not yet been evaluated. We developed a rat model of skeletal muscle ischemia and measur...
We investigated progression and recovery of neuronal damage during and after global cerebral ischemia in gerbils after bilateral occlusion of the common carotid arteries, using the immunohistochemical method (reaction for tubulin and creatine kinase BB-isoenzyme). The earliest, but reversible, ischemic le...
Ischemic preconditioning (IP), using one or more brief periods of ischemia before a sustained ischemia, represents a new approach to reduce tourniquet ischemia-induced skeletal muscle damage. The aim of this study was to investigate the effect of IP on skeletal muscle function and high-energy phos...
Both pharmacological inhibition and gene deletion of sEH attenuate acute cerebral infarction, ischemia-induced sEH activity, and sensorimotor deficits Consistent with previous studies15,26, we found that both the AUDA-treated mice and soluble epoxide hydrolase knockout (sEH KO) mice exhibited a signific...