The criteria associated with each alternative regimen were side effects, practicability, size of tablet, number of tablets, drug-drug interaction, pregnancy, genetic barrier, glomerular filtration rate of the k
There are some exceptional circumstances, however, in which a 2-drug regimen may be used, especially when the ideal recommended antiretroviral medications are unavailable, or there is concern about potential adherence problems or toxicity. An HIV expert should always be consulted if a 2-drug PEP ...
Optimal HIV Postexposure Prophylaxis Regimen Completion With Single Tablet Daily Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine Compared With More Frequent Dosing RegimensMayer, Kenneth H.Jones, DanielOldenburg, CatherineJain, Sachin
A recent study has been the first to effectively demonstrate that a two or three drug regimen is more effective than mono- therapy for nonoccupational PEP.13 This study also showed that dual therapy can be as effective as triple therapy, with no difference in efficacy seen. The cost benefit...
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China; ABSTRACT Objective: Evaluate the profiles of post-exposure prophylaxis (PEP) adherence, adverse drug reactions (ADRs), and discontinuation associated with ADRs to provide information for further PEP program improvement and increa...
Guidelines from the United States Public Health Service (USPHS) [1] and New York State Department of Health AIDS Institute [2] recommend that, after any occupational exposure to HIV, healthcare personnel should immediately receive PEP 3-drug regimen. Specific recommendations also include the followin...
Post-exposure prophylaxis (PEP) is a well-established strategy for the prevention of infectious diseases, in which recently exposed people take a short course of medication to prevent infection. The primary objective of the COVID-19 Ring-based Prevention
and poor compliance in completing treatment regimen, partly due to drug toxicity [9–11]. Therefore, a regimen of pre-exposure prophylaxis is being evaluated for preventing HIV infection in high-risk, HIV-negative persons, such as sex workers whereby highly potent antiviral drugs are taken before...
(Isentress®), in part based on improved tolerability and higher completion rates of the 28-day recommended course for both nPEP and oPEP. With the most recent update in October 2014,dolutegravir(Tivicay®) became an additional choice for the third drug, so the preferred regimen is now ...
(leprae/ tuberculosis): mycobacterium; MB: multibacillary; MDT: multi drug treatment; NLR: Netherlands Leprosy Relief; PB: paucibacillary; PEP: post-exposure prophylaxis; PEP++: post-exposure prophylaxis enhanced regimen; SDR: single dose rifampicin; TB: tuberculosis Acknowledgements The Expert Meeting...