The criteria associated with each alternative regimen were side effects, practicability, size of tablet, number of tablets, drug-drug interaction, pregnancy, genetic barrier, glomerular filtration rate of the kidneys and being a member of a key population. These criteria linked with their weights ...
Antiretroviral Drug Regimens The US Public Health Service (PHS) no longer recommends that the severity of exposure be used to determine the number of drugs to be offered in an HIV PEP regimen. Regimens should contain 3 (or more) antiretroviral drugs for all occupational exposures to HIV. The ...
A postexposure rabies prophylaxis regimen involving a series of four-site injections over the course of one week may have more immunogenicity than the frequently-used two-site intradermal regimen, according to results of a recent study. Participants in one arm of the study received four-site intra...
Sexual assault victims should also be offered postexposure prophylaxis. Treatment should be initiated as soon as possible after a potential exposure (preferably within 36 hours) and should be continued for 28 days. Weekly contact by telephone or e-mail may improve adherence to the treatment regimen...
Optimal HIV Postexposure Prophylaxis Regimen Completion With Single Tablet Daily Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine Compared With More Frequent Dosing RegimensMayer, Kenneth H.Jones, DanielOldenburg, CatherineJain, Sachin
Renal and Bone Adverse Effects of a Tenofovir-Based Regimen in the Treatment of HIV-Infected Children: A Systematic Review Studies that involved the use of TDF for pre- and post-exposure prophylaxis, and treatment of chronic hepatitis聽B virus infection were excluded. Data on... Rose,I.,Okonk...
Three-drug regimens are routinely recommended in the UK for PEP after possible high-risk exposure to HIV. The current Department of Health and British Association for Sexual Health and HIV first-line regimen is lopinavir/ritonavir, tenofovir and emtricitabine (Truvada). Raltegravir-based regimens may...
Given concerns over efficacy of a 2-NRTI regimen, would recommend a 3 or 4 drug PEP regimen ? Resistance to PIs: difficult to estimate, but PI resistance generally evolves less rapidly than does resistance to the NRTI components of typical ART regimens ? Would not expect any resistance to ...
If a third drug is added,a protease inhibitor, often boosted withlow-dose ritonavir(e.g., ritonavir-boosted atazanavir, lopinavir, or darunavir), is commonly used; the use of a ritonavir-boosted regimen serves to improve...
If a third drug is added,a protease inhibitor, often boosted withlow-dose ritonavir(e.g., ritonavir-boosted atazanavir, lopinavir, or darunavir), is commonly used; the use of a ritonavir-boosted regimen serves to improve the pharmacokinetics. ...