Recent experimental work has revealed that the effects of different treatments in melanoma are related to the activation of BH3-only proteins, and also the proapoptotic effects of BRAF inhibitors are prevented by knockdown of the BH3-only protein Bim. Thus, melanoma therapy might be critically ...
The potential for hyperthermia and chemotherapy in the treatment of specific human cancers, both disseminated and solid tumors, are discussed with respect to current therapy and the possible benefit of hyperthermia treatment. 展开 关键词: Humans Lymphoma Melanoma Breast Neoplasms Gastrointestinal Neoplasms ...
Unfortunately, available Chokα inhibitors also have toxic side-effect and are not approved for use in patients. Hopefully, this research might encourage screening for safe drugs interfering with these pathways and contribute the development of new treatments for AITL....
This relative dearth of research devoted to chaperone protein targets and therapeutics in brain tumors reveals much untrodden turf to explore for potential treatments of these dreadfully refractive diseases. 展开 被引量: 74 年份: 2005 收藏 引用 批量引用 报错 分享 ...
As another COVID-19 summer surge hit the US this year, many infected people likely were prescribed the antivirals nirmatrelvir and ritonavir, better known as Paxlovid, for the first time. Or for the fourth time. Or somewhere in between. ...
This discovery led to the successful instigation of dopaminergic drug treatments in the 1960s, although these... RA Barker,J Drouin-Ouellet,M Parmar - 《Nature Reviews Neurology》 被引量: 100发表: 2015年 Aβ immunization and anti-Aβ antibodies: potential therapies for the prevention and ...
. Currently, tumor thickness and the presence of ulceration are some of the known prognostic factors used as indicators of malignant melanoma. Therefore, the discovery of valuable markers to assess the malignant potential of melanoma more accurately may be necessary to develop appr...
Abstract 4949: Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigen p>The impact of intratumor heterogeneity (ITH) and the neoantigen landscape on T cell immunity is poorly understood. ITH is a widely recognized feature of ... GP Linette,BM ...
Here, the threshold of tolerable side-effects may also be higher due to a limited duration of therapy and the considerable adverse effects associated with alternative cytostatic treatments. Currently, several phase I and phase II clinical trials with patients suffering from malignant central nervous ...
viruses Review NSP16 2 -O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments Strategies Li-Jen Chang 1,2 and Tsung-Hsien Chen 2,* 1 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospit...