"This study contributes to the understanding of how the GABA system is affected by both pharmacologic and behavioral interventions and will help to guide the development of new treatments for low GABA states," said co-author Domenic Ciraulo, MD, professor and chairman of the department of psychiat...
Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments. Neurosci Biobehav Rev. 2017;75:157–65. Article CAS PubMed Google Scholar Vallée A, Lecarpentier Y, Guillevin R, Vallée J-N. Effects of cannabidiol interactions with ...
Beyond age considerations, the current data also support a very important role for biological sex and suggest that pharmacological treatments would likely have to be evalu- ated separately in both sexes [3, 13, 15, 16]. A greater num- ber of dysregulated sncRNAs and their gene targets and ...
This method of analysis provides opportunities for identification of new pathways critical for the disease development and as targets for better treatments. Despite the identification of the same pathways in two different populations, findings of this method need to be confirmed by other approaches such...
Anti-TNF treatments in rheumatoid arthritis: economic impact of dosage modification Rheumatoid arthritis (RA) is a chronic systemic disease that leads to increases in health system economic burden through direct and indirect costs, includi... IDL Torre,L Valor,JC Nieto,... - 《Expert Review of ...
Adopting small-world neural networks of the Hodgkin-Huxley (HH) model, the stimulation parameters in desynchronisation and its possible implications for vagus nerve stimulation (VNS) are numerically investigated. With the synchronisation status of networks to represent epilepsy, then, adding pulse to st...
Administration of 120 mg/kg of pregabalin through the conditioning phase showed no significant change over phase [F (1, 10) = 0.8837, p = 0.3693] or between treatments [F (1,10) = 0.04083, p = 0.8439], and there was no considerable association between phase and trea...
This method of analysis provides opportunities for identification of new pathways critical for the disease development and as targets for better treatments. Despite the identification of the same pathways in two different populations, findings of this method need to be confirmed by other approaches such...
Doctors usually reserve this invasive therapy for people with severe conditions, such as those with epilepsy whose seizures have not improved with any other treatments. [10 Things You Didn't Know About the Brain] "Deep-brain stimulation is very useful for helping a lot of people, but it does...
For this purpose, different doses of MEL (2, 4 or 16 mg/kg) or DZ (2 mg/kg) are subchronically administered during 15 days. After pharmacological treatments, anxiety levels are evaluated in behavioral tests of Open Field (OFT) and elevated plus maze (EPM) and depression levels are ...