Some mechanisms reviewed which may induce or contribute to a ventilatory threshold are the effect of: (a) the carotid bodies; (b) respiratory mechanics; (c) temperature; and (d) skeletal muscle receptors. It is not yet possible to determine the hierarchy of effects essential for generating a ...
Polyploidy is typically described as the condition wherein a cell or organism has more than two complete sets of chromosomes. Occurrence of polyploidy is a naturally occurring phenomenon in the body’s development and differentiation processes under normal physiological conditions. However, in pathologic...
It has been previously reported that central administration of some neurotoxicants causes significant impairement in motor functions, increased neuroinflammation and increased drug addiction68,69,70. Post-treatment with CEF (200 mg/kg) significantly antagonized motor impairment, attenuated lipid ...
Clays, desert dust and biological particles may be effective, although to what extent is unclear. Artificial nuclei include Silver Iodide and dry ice, and these form the basis of cloud seeding. Once a droplet has frozen, it grows in the supersaturated environment (air saturated with respect to...
McMurray Journal of Biological Chemistry Jan 2001 Calmodulin Kinase II (CamKII) inhibits the transcription of many CRE-dependent genes, but the mechanism of dominant transcriptional inhibition is unknown. Here we show that phosphorylation of serine 142 in CREB by CamKII leads to dissociation of the ...
Surprisingly, subjects’ performance significantly improved in the second run of ODT compared to the first one regardless of the tDCS stimulation type they received (anodal, cathodal, or sham-tDCS). Possible causes for such an improvement could have been due to either a generic “placebo” effect...
although the binding affinity of the construct (dissociation constant,Kd = 17.2 ± 7.1 nM) was lower than that of the WT ghrelin receptor (Kd = 4.42 ± 0.76 nM) (Supplementary Fig.3d). Fab 7881 binds to intracellular loop 3 (ICL3); the flexibility of ICL3 ...
Moving forward, research should focus on the biological properties of the aforementioned viruses using virus isolation, reverse genetics, in vitro and in vivo infection experiments, as well as other methods. The information gathered would help in the future prevention and control of disease epidemics ...
Redox-cycling of doxorubicin by flavoenzymes makes the heart more vulnerable to oxidative stress leading to cardiac dysfunction. The present study evaluates the role of neferine, a bisbenzylisoquinoline alkaloid, in curbing the molecular consequences of DOX-exposure in H9c2 cardiomyoblasts. Neferine pre...
A melting curve was created over a temperature range of 60 to 95 °C after each run to ensure the absence of nonspecific product amplification. Amplification specificity was confirmed by dissociation curve analysis. Specificity of the amplified product was additionally tested on 1% agarose gel. ...