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negative B-cell lines, those with the same G6PD isoenzyme as the Thus, although there is evidence that BCR-ABL1 can initiate a patient's own leukaemia showed multiple non-Ph cytogenetic myeloproliferative disease in experimental animals, there is abnormalities, whereas those with the non-leukaemia...
Immunity Versus Tolerance: The Cell Biology of Positive and Negative Signaling of B LymphocytesThis chapter focuses on the positive and negative signaling of B lymphocytes has concentrated on the cellular physiology of immunity and tolerance. While the broad outlines of the key inductive events are ...
Next, miR-21 inhibitor was loaded into the modified exosomes by electroporation. We found that the exosome markers Flotillin-1, TSG101 and CD9 were detected in the Dex loaded with miR-21 inhibitor, and the negative marker Calnexin was absent (Fig.S6A). There was no difference in morphology...
These previous data brought us an idea that the establishment of nucleus-mitochondria positive feedback loop induced by chemo-radiation may play a key role for inducing persistent and irreversible SASP. To the best of our knowledge, we could not find any paper even review, except for ours, ...
To investigate the influence of the tTAV feedback circuit on gene activity, we assessed the changes in the transcriptome with and without tetracycline. This system provides an ideal internal control when examining flies raised with versus without tetracycline, as it allows us to differentiate transcri...
5a). Twenty-four hours after transfection with miR-195 mimic, miR-195 inhibitor, or negative control, HCC cells were treated with 1000 ng/mL LPS for another 24 h and then analyzed for intracellular cholesterol levels and related gene expression. Relative to the controls, mRNA and protein ...
The signals for Tau1 or NF200 and myelin basic protein (MBP) did not overlap, and some white matter tracts were presented in a MBP-intermittent or MBP- negative manner (Fig. 1h,i). These results suggest that some GSCs in the glioma-brain interface are preferentially located adjacent to ...
S7). This is consistent with predominantly negative selection on ORF1a, but occasional mutations under positive selection. We observed a similar split of cluster growth rates for ORF8 and spike when classifying mutations by type and previously inferred positive fitness. These results suggest that our...
lending support to the notion that XAF1C is a dominant-negative inhibitor of XAF1A and its preferential expression contributes to tumor progression. Given that both XAF1 and IRF-1 are frequently inactivated in multiple human cancers, it is conceivable that disruption of the XAF1−IRF-1 axis...