This screen also identified novel ligands for intramembrane low affinity diazepam site(s). In the current study we have further characterized compounds 31 and 132 identified with EGVS as well as 4-O-methylhonokiol. We investigated the site of action of these compounds in α1β2γ2 GABAA ...
cancers Article MiR-375 Regulation of LDHB Plays Distinct Roles in Polyomavirus-Positive and -Negative Merkel Cell Carcinoma Satendra Kumar 1,2,†, Hong Xie 1,2,3,† , Patrick Scicluna 1,2,4, Linkiat Lee 1,2, Viveca Björnhagen 5, Anders Höög 1,2,6 , Catharina Larsson 1,2...
The current debate around the specificity and correlation with outcome is the reason why several groups are cautious in using p16INK4a IHC as a standalone marker and are suggesting p16INK4a IHC Cancers 2016, 8, 41 7 of 16 as an initial screen for direct HPV detection methods. Of note, ...
Moreover, early hits from a fragment screen generally bind more efficiently, even if not strongly, to their target and represent desirable starting points for medicinal chemists to grow and optimize these into lead candidates. Interestingly, this strategy has been largely applied in discovering ...
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