Finally, in view of its pivotal role in cellular antigen presentation and major histocompatibility complex (MHC) class-1 regulation, we hypothesized that the shear-dependent induction of TOP may lower MHC1 expression. In this respect, we observed that recombinant TOP over-expression in static HAECs...
allosteric regulation anesthesia Cys loop receptor GABA receptor homology modeling photoaffinity labeling Introduction For over 150 years, drug screens assessing in vivo animal responses have led to the identification of a structurally diverse group of compounds, including simple volatile ethers, alcohols, ...
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coli, involved in the regulation of replication initiation timing, or mutH, the endonuclease recognizing the newly synthesized strand during mismatch repair at hemi-methylated 64 47 57 77 38 210 72 (2%) 112 (3%) 84 (2%) 100 (3%) 168 (4%) 273 (7%) 2,126 (53%) singlets doublets ...
The programmed death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in the pathogenesis of Epstein-Barr virus-positive diffuse large B cell lymphoma, not otherwise specified (EBV+ DLBCL, NOS). Here, we describe PD-L1 expression by EBV+ DLBCL, NOS in order to evaluate its possi...
This inhibition dysregulates the divisome and elongasome supported by an upregulation of key proteins FtsZ, DivIVA, and MreB inducing cell division arrest. The inhibition of ClpXP and ClpYQ to dysregulate cell division represents a unique antibiotic mechanism of action and armeniaspirol is the ...
Invasive infection by the Gram-positive pathogen Staphylococcus aureus is controlled by a four gene operon, agr that encodes a quorum sensing system for the regulation of virulence. While agr has been well studied in S. aureus, the contribution of agr homologues and analogues in other Gram-positi...
The virion structure is similar to that of T7 and P22, except that the tail tube is extended by a distal knob formed by a hexamer of gp9 and probably two copies of gp13 [140]. The latter possess an N-terminal lysozyme-like domain and a C-terminal endopeptidase activity that are ...
Valerio, Awad: "β-Sitosterol down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in J774A.1 murine macrophages." in:International immunopharmacology,Vol. 11,Issue 8,pp. 1012-7, (2012) (PubMed). ...
Our data suggest that regulation of Separase in IM-treated BCR-ABL-positive cells occurs on both the protein expression and the proteolytic activity levels. Activation of Separase proteolytic activity exclusively in p210BCR-ABL-positive cells during IM treatment may act as a driving force for ...