(Arg153Leu) within a protein kinase A recognition motif that abrogates protein kinase A's negative regulation of the activity of the PDZ-binding domain... Watson,A R. - 《Journal of Cell Science》 被引量: 233发表: 2003年 Mechanisms of regulation of cell adhesion and motility by insulin re...
In regard to melanocytes, which can directly affect repigmentation after grafting, GSVA (Gene set variation analysis) using Reactome and GO database showed that pathways including “melanin biosynthesis”, “PI3K-AKT signaling”, “cell-cell adhesion”, and “positive regulation of melanocyte different...
we trained with positive levels from 0.1 to 0.9. The positive level of 0.5 shows the highest area under the estimated ROC curve (AUROC = 0.98) (Supplementary Fig.3). Proteins were ranked based on probability scores, which is defined as the proportion of trees in the ensemble ...
Our first objective was to determine whether unbiased single-cell clustering could identify valve cell types, discover new cell phenotypes using established markers, and improve existing classifications. Our second objective was to investigate the potential of single-cell analysis for elucidating the underl...
Torensma R,Nelissen JM,van Kooyk Y,Raymakers RA,Pennings AH,de Witte T.Figdor CG Regulation of LFA-1 Expression by CD34 Positive Cells and Inducible Growth Factor Production by Stroma Enable Formation of Bone Marrow Compartments;Subject Heading. Hematology . 2000...
Engagement of the antigen-receptor complex (TcRζ/CD3) on T cells is insufficient for the development of an optimal response against foreign antigen. Instead, T cells require at least two signals for optimal T-cell expansion (Bretscher 1999). Peptides pr
HER2 upregulation enhances the role of growth signals in the extracellular environment, promoting cell survival and proliferation through various downstream effects. Drugs targeting HER2 can block this downstream effect and improve outcomes in patients with HER2-positive breast cancer, but also increase th...
Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin PD Kassner - 《Journal of Experimental Medicine》 被引量: 175发表: 1993年 Interchangeable α chain cytoplasmic domains play a positive role in control of cell ...
thereby rendering it a promising therapeutic target [30]. Reduced B7-H3 expression in MM correlates with enhanced progression-free survival, whereas its upregulation is implicated in heightened drug resistance and tumor advancement [24]. This study investigates the anti-leukemia activities of αB7-H3...
S1), we found that some significant enrichment was observed, but mostly for broad functional categories, such as GO:0050794 regulation of cellular process (padj = 2.632 × 10–17) and GO:0140053 mitochondrial gene expression (padj = 4.751 × 10–7). We also tested this...