Immunology Regulation of cluster of differentiation eight positive (CD8+) T cell homeostatic proliferation UNIVERSITY OF MINNESOTA Stephen C. Jameson JohnsonLisa Danae SchultzThe adaptive immune system provides protection against pathogens during a primaryinfection and generates a reservoir of memory cells ...
Moreover, IL-12-dependent transcriptional up-regulation of T-bet and STAT4 was deficient in the HSA(+) CD4 SP thymocytes. Thus, the poor capacity of HSA(+) CD4 SP thymocytes to proceed to T(h)1 cell differentiation appears to be at least partly due to underdeveloped capacity in IL-12R...
Regulatory gene circuits with positive-feedback loops control stem cell differentiation, but several mechanisms can contribute to positive feedback. Here, we dissect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and myeloid differentiation. Quantitative live-cell imaging ...
Survivin, a unique member of the IAP protein family, serves as a dual regulator of cell division and apoptosis18. Mounting evidence has suggested survivin as a pivotal oncoprotein with multiple roles in the regulation of mitosis, suppression of cell death, and enhanced adaptation to cellular ...
Division of BiologyAmerican Association for the Advancement of ScienceScienceKueh HY, Champhekar A, Nutt SL, Elowitz MB, Rothenberg EV (2013) Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science 341(6146):670–673. : 10.1126/science.1240831...
“positive regulation of cell adhesion mediated by integrin” and “cell junction maintenance”, “keratinization”, “hair follicle maturation”, and “epithelial mesenchymal cell signaling”, and so on (Fig.5c, d). Upregulated pathways between DCN+ fibroblasts and ZNF90+ fibroblasts were ...
Selection events on coding sequences may also have effects on gene expression regulation. One transcription factor that showed signs of positive selection along the human lineage was HIVEP3(immunodeficiency virus type I enhancer binding protein 3). This gene belongs to a family of zinc-finger protei...
Dunseth et al. underlined the necessity of differentiation between analytical false-positive results of lues tests from clinical false-positive results. A positive syphilis IgG screen with negative RPR and T. pallidum particle agglutination assay (TP-PA) confirmatory testing could be considered an analy...
Mitogen-activated protein kinases facilitate many cellular processes and are essential for immune cell function. Their activity is controlled by kinases and dual-specificity phosphatases. A comprehensive microarray analysis of human leukocytes identified
Lymph node status is usually one of the most important prognostic factors in solid cancer. The current neck staging for salivary gland carcinoma is entirely based on the 8th AJCC system calculated from head and neck squamous cell carcinoma20, which takes lymph node size, laterality, and extranodal...