16, Pages 27015-27031: Sildenafil Protects against Myocardial Ischemia-Reperfusion Injury Following Cardiac Arrest in a Porcine Model: Possible ... Sildenafil suppressed AT1R up-regulation, but had no effect on ACE, ACE2, and Mas expression. Sildenafilfurther boosted the upregulation of endothelial ...
We tested hypothesis that upregulation of hypoxia inducible factor-1 (HIF-1) would improve the actions of positive inotropic agents in cardiac myocytes after simulated ischemia-reperfusion. HIF-1伪 was upregulated with deferoxamine (150 mg/kg/day for 2 days). Rabbit cardiac myocytes were ...
stress often leads to widespread oxidative damage and cell death, a moderate level of oxidative stress, induced by a variety of stressors, can yield great beneficial effects on adaptive cellular responses to pathological challenges in aging and aging-associated disease tolerance such as ischemia ...
Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat Commun. 2020;11(1):1315. Article ADS PubMed PubMed Central Google Scholar Gong L, Zheng X, Zhang W, Shu Z, Wang H, Dong Q et al. CD4 + CD25 +...
However, we found that the number of EYFP þ O1 þ oligodendroglial cells in the cerebellum was increased in response to hypoxic–ischemic injury in the PVL mice compared with the controls (Figures 8g, h, and i, Po0.01), likely because of a reactive response to hypoxia–ischemia. ...
Hypertensive rat Survival Transient focal ischemia 1. Introduction The need for robust pre-clinical models of stroke is well recognised given the poor translation from bench to bedside for stroke interventions. Often, pre-clinical studies fail to consider co-morbidities associated with stroke clinical ...
This speculation is strongly supported by previous study indicating that renal ischemia caused by vascular obliteration is a major contributor to renal fibrosis [3]. Moreover, the tubular epithelium is a source of VEGF in the tubulointerstitium [44]. Therefore, we concluded that injury and/or ...
Using long-term label retention assays, a low-cycling cell population that was able to divide rapidly to repair the transient renal ischemia-induced damage was found in the papillary region. These cells were able to incorporate into other renal tissues, form spheres in 3D cultures, and exhibit ...
ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in ...
Heart damage also can include wounds, such as for example, knife wound; biological (e.g. viral; autoimmune diseases) or chemical (e.g. chemotherapy, drugs); surgery; transplantation and the like. “Myocardial ischemia” can refer to a lack of oxygen flow to the heart which results in ...