These findings in yeast raise the following question: are there similar positive-feedback loops that function within mammalian restriction point and G1–S control? One well-known loop is the expression of cyclin
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development 137, 4051–4060 (2010). Article CAS PubMed Google Scholar Sha, W. et al. Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts. Proc. ...
Collectively, our study indicates that EBP2 is a novel binding partner of c-Myc that regulates the function of nucleolar c-Myc, cell proliferation, and tumorigenesis via a positive feedback loop.doi:10.1038/CDDIS.2013.536P LiaoW WangM Shen...
In this section, we limit our discussion to Hill model-based modeling to quantify the feedback. For any two interacting components, X and Y, Hill function represents the biomolecular interactions describing the dynamics as follows (Mangan and Alon, 2003; Locke et al., 2005; Smolen et al., ...
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The tTAV positive feedback systems function as expected in each insect species tested, in that tTAV expression is repressible with dietary tetracycline and lethal without it. However, the timing of lethality varied among species and even between insertion sites within the same species. In P. ...
One qualitative network feature has in particular been linked to multi-stationarity, namely the existence of apositive feedback loop. A positive feedback loop consists of a sequence of species such that each species affects the production of another species, either positively or negatively, and such...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Overall, this work reveals the critical role of MSCs in the glioma microenvironment as signal multipliers to enhance immunosuppressive signaling of glioma exosomes, and disrupting the positive feedback loop in MSCs with modified Dex could improve PD-1 blockade therapy. ...
G Cartoon illustration of the positive feedback loop of HBx-ALKBH5.WT, widetype; MT, mutant which may form a positive loop between HBx and ALKBH5 (Fig. 6G). Discussion HBV exerts its tumor-promoting function by inducing ab- normal epigenetics regulation of host cells, however, whether the...