In addition, p62 is a stress-inducible protein whose expression is regulated by Nrf2 (ref. 10), and p62 overproduction is sufficient for phosphorylation of p62 to inactivate Keap1 (ref. 9), resulting in a positive-feedback loop that accelerates Nrf2 activation. Thus, chronic inflammation in ...
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affecting Nrf2 activation (Fig. 5d). Importantly, BSO addition reduced the concentration of GSH in S351E-expressing Huh7 cells back to control levels (the level in GFP-expressing Huh7 cells in the absence of BSO,Fig. 5c), and it also suppressed growth stimulation by S351E (Fig. 5e). ...
Collectively, ENO1 promotes tumor cell migration and invasion by orchestrating IL-6 secretion of macrophages via a dual mechanism, thus forming a positive feedback loop to promote OSCC progression. ENO1 might be a promising therapeutic target which is expected to control OSCC progression. Keywords:...