Homeostasis is defined as the maintenance of a stable internal environment within the body in an ever-changing external environment. There are two mechanisms to create a steady internal environment. One mechanism is referred to as negative feedback- this process controls the levels of many important...
This study reveals the critical role of another cell cycle regulator, CDCA3, in modulating glycolysis in BLCA, underscoring the significance of the CDCA3-MYC feedback loop in promoting BLCA progression. MYC, a key oncogenic transcription factor, plays a central role in the metabolic reprogramming ...
The positive feedback loop between the two might promote the progression of hepatocellular carcinoma. Nrf2, as a transcription factor, could bind to the ARE sequence in the downstream gene promoter region, thus advancing the downstream genes’ expression. Nrf2 had been reported to form feedback ...
The positive feedback loop between HMGB1 and TREM2 cascade the regulation of TLR4/Akt signaling pathway. (A) The Spearman correlation heat map of TREM2 and TLR genes (TLR1 ~ TLR10) analyzed by TIMER2.0 database; The protein-protein interaction network (B) and the co-expression relation...
Fluctuations in food availability and shifts in temperature are typical environmental changes experienced by animals. These environmental shifts sometimes portend more severe changes; e.g., chilly north winds precede the onset of winter. Such telltale si
Concurrently, MYC enhances CDCA3 transcription, forming a positive feedback loop that drives BLCA progression through ENO1-mediated glycolysis. Materials and methods Cell culture All cell lines used in this study were obtained from the Cell Bank of the Chinese Academy of Sciences. T24 and 5637 ...
Here, we attempt to further verify the role of the p53/miR-34a/SIRT1 positive feedback loop in the termination of liver regeneration and its possible relationship with liver cancer. Method: We performed partial hepatectomy (PH) in mice transfected with adenovirus (Ade) overexpressing P53 and ...
Articles https://doi.org/10.1038/s41593-018-0285-z Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop Jun Wang1,2,12, Sen-Lin Xu1,12, Jiang-Jie Duan1,2,12, Liang Yi3,12, Yu-Feng Guo1,2, Yu Shi1, Lin ...
Conclusions Our results revealed the important role of circPVT1 in the progression of NPC through the β-TrCP/c-Myc/SRSF1 positive feedback loop, and circPVT1 may serve as a prognostic biomarker or therapeutic target in patients with NPC.Back...
Circular RNA (circRNA), a closed continuous loop formed by back-splicing, has been confirmed to be implicated in a variety of human diseases including cancers. However, the underlying molecular mechanism of circRNA regulating the progression of renal cel