A way of raising the effect size may be to facilitate agonist-induced responses by co-administering a nAChR positive allosteric modulator (PAM). Objective: The aim was to test whether galantamine, a PAM at several nAChR subtypes, can potentiate the cognitive-enhancing effects of nicotine. Methods...
(2009). Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Research, 69(16), 6633–6641. Article CAS Google Scholar Cummings, K. M., & Hyland, A. (2005). Impact of nicotine replacement therapy on smoking behavior. Annual ...
Also, this compound did not alter the antinociceptive effects of 1 mg/ kg nicotine (Supplementary Figure 5). In the drug discrimination assay, ZCZ011 (40 mg/kg) significantly increased the potency of the discriminative stimulus effects of AEA in FAAH ( − / − ) mice (F (4,48) = ...
Positive effect of Mo on mechanical properties of a Ni-42W-10Co-xMo medium heavy alloy Moreover, as the Mo content increases from 0 to 10wt.%, the distribution of the 渭-phase shifts from being individually dispersed to forming aggregates... Cao, Guo-xin,Dong, Jian-xin,He, Yong-sheng...
The rank order of potency to increase stimulation-evoked release for the nAChR agonists (nicotine > DMPP cytisine) suggests that the β4 subunit of nAChRs is not involved in the release. The finding that α-bungarotoxin was effective in preventing the effect of DMPP and itself significantly ...
BINA decreased cocaine self-administration in both ShA and LgA rats, with no effect on food self-administration. Alternatively, LY379268 nonselectively decreased both cocaine and food self-administration. BINA decreased cue-induced reinstatement of cocaine seeking with no effect on food seeking. The ...
Another recent study investigated the cross-talks between HER-2 and ER pathways and the effect of HER-2 blocking agents on the tyrosine kinase effector transcription factor Myc, showing that elevated Myc protein was inversely associated with pCR. In HER-2 positive cells trastuzumab can repress Myc...
Given the implications for smoking among individuals living with HIV and the high rates of smoking and HIV among men who have sex with men (MSM) in China, we examined differences in prior use of and future interest in various cessation r... CJ Berg,EJ Nehl,X Wang,... - 《Nicotine &...
Chronic treatment with AZD8418 attenuated nicotine self-administration, but tolerance to this effect developed quickly. The inhibition of nicotine self-administration by chronic AZD8529 administration persisted throughout the 14 days of treatment. Chronic treatment with either PAMs inhibited food self-...
Various forms of exercise have been shown to prevent, restore, or ameliorate a variety of brain disorders including dementias, Parkinson’s disease, chronic stress, thyroid disorders, and sleep deprivation, some of which are discussed here. In this review, the effects on brain function of various...