The sirtuin family has been shown to play critical roles in cellular stress-response systems by regulating gene expression, DNA damage repair, metabolism, and cell survival. Structurally, sirtuins were found to consist of a large Rossman-fold NAD+-binding domain, a small zinc-binding domain, and...
et al. Trastuzumab deruxtecan (T-DXd; DS-8201) with nivolumab in patients with HER2-expressing, advanced breast cancer: a 2-part, phase 1b, multicenter, open-label study. Cancer Res. 81 (Suppl. 4), PD3-07 (2021). Article Google Scholar Emens, L. A. et al. Trastuzumab emtansine...
(2017). Positive affect and physical activity: Testing effects on goal setting, activation, prioritisation, and attainment. Psychology & Health, 33, 1-7.Cameron, D. S., Bertenshaw, E. J., & Sheeran, P. (2017). Positive affect and physical activity: Impacts on goal setting, activation,...
Conjunctive p16INK4a testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasia. Am J ClinPathol. 2010;133:395–406. 9. Stoler MH, Schiffman H. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-...
DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a promising antitumor efficacy with differentiation from T-DM1. Clin Cancer Res. 2016;22(20):5097–5108. 52. Nakada T, Sugihara K, Jikoh T, et al. The latest research and development into the...
A recent hepatitis B vaccination (HepB) can also cause a positive HBsAg test result. If you received a dose of the HepB vaccine within 30 days of your test, your healthcare provider may recommend waiting another month before retesting. ...
Tamura K, Tsurutani J, Takahashi S et al (2019) Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study. Lancet Oncol 20:816–826 Article CAS PubMed Google Scholar Tarantino P, Ca...
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics. 1989;123:585–95. 75. Zivković D, Wiehe T. Second-order moments of segregating sites under variable population size. Genetics. 2008;180:341–57. 76. Ramírez-Soriano A, Nielsen R. Correcting ...
Host-cell DNA methylation analysis can be used to triage women with high-risk human papillomavirus (HPV)-positive self-collected cervicovaginal samples, but current data are restricted to under-/never-screened women and referral populations. This study evaluated triage performance in women who were ...
Chemical Stress Testing By comparing antibody primary sequence data to experimentally observed degradation events, it has become clear that certain sequence motifs may be prone to degradation (i.e, aspartate isomerization at DD, DG, and DS sequences and asparagine deamidation at NG sequences). If ...