Similar results were achieved when evaluating TB in both 1 and 10 HPF, indicating the applicability of TB assessment in both biopsy and resection specimens [37]. However, we recommend the 10 HPF method for evaluating TB if feasible as it has shown better reproducibility [33]. The negative ...
However, tumor biopsy is challenging because the procedure is invasive and may lead to inadequate sample collection. Peripheral blood, as a feasible and sensitive alternative, is appealing for investigating predictive biomarkers for immunotherapy because of its noninvasiveness, easy accessibility, and ...
Next, we refined exams with biopsy-proven benign findings to determine if the pathology results were deemed by the radiologist to be concordant or discordant with the imaging features of the breast lesion. Patients with biopsy reports that confirmed a discordant benign finding were only included in...
Many such reagents are used to determine clonality of cells (that is, has the neoplasm been derived from a single neoplastic cell) in a biopsy specimen. Confirmation of clonality is an important step for diagnosis of cancer. Once clonality is established, other markers can be used as prognostic...
In particular two 10 μm sections of each biopsy were extracted twice with 1 ml of xylenes, for paraffin removal, and twice with 500 μl of 100% ethanol, for organic solvents re- moval. Both xylenes-treated and fresh tissue samples were digested with Proteinase K (150 μg per ml at ...
Further molecular testing performed in her tumor biopsy revealed high mRNA expression of AXL and CDCP1. The patient was included in the AZENT (AZD9291 in EGFR-mutation-positive NSCLC and concomitant Thr790Met pre-treatment) study (NCT02841579) and started first-line treatment with osimertinib. ...
Breast cancer (BC) is a complex disease with primary or acquired incurability characteristics in a significant part of patients. Immunotherapeutical agents represent an emerging option for breast cancer treatment, including the human epidermal growth fac
Our working database includes results of pathology reports, including tumour histology and grade and standard IHC analyses for ER and progesterone receptors for primary breast cancer biopsies and surgical specimens as well as local and distant recurrences that were subject to biopsy or surgical excision...
Our working database includes results of pathology reports, including tumour histology and grade and standard IHC analyses for ER and progesterone receptors for primary breast cancer biopsies and surgical specimens as well as local and distant recurrences that were subject to biopsy or surgical excision...
Breast carcinomas of the HER2-positive subtype LB: Liquid biopsy NGS: Next generation sequencing PBMCs: Peripheral blood mononuclear cells PD: Progressive disease PFS: Progression-free survival PR: Partial response SD: Stable disease SoC: Standard of care T-DM1: Trastuzumab-emtansine ...