2.3.13 Positive feedback and stability In Figure 2.76 a negative feedback signal is produced by using a series voltage. If the phase of the series voltage was changed such that the feedback signal augmented the input, then the nature of the feedback loop would become positive. With this po...
A relatively simple model with negative feedback can be constructed by adding a second TF to the model of Fig. 14.11A. As diagrammed in Fig. 14.13A, this second TF, termed TF-R, represses transcription of both its own gene and that for the transcriptional activator, TF-A. In turn, ...
CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-α/NF-κB signaling Yang Jiang, Junshuang Zhao, Yingliang Liu, Juntao Hu, Liang Gao, Hui Wang & Daming Cui Cell Death & Disease volume 13, Article number: 697 (2022) Cite this article ...
Thus, these results suggest a negative feedback loop between AML1-ETO and YTHDF2 that maintains the stable expression level of the two proteins. Although the oncogenic role of FTO has been reported in leukemia, the functional significance of FTO in some leukemic cells, such as the human ...
Furthermore, HIF2α specific inhibitor could repress PVT1 expression and its oncogenic functions. Therefore, our study demonstrates that the PVT1/ HIF2α positive feedback loop involves in tumorigenesis and progression of ccRCC, which may be exploited for anticancer therapy....
Synthetic systems that use positive feedback have been developed to control human disease vectors and crop pests. The tTAV system, which has been deployed in several insect species, relies on a positive feedback circuit that can be inhibited via dietary tetracycline. Although insects carrying tTAV...
Overall, this work reveals the critical role of MSCs in the glioma microenvironment as signal multipliers to enhance immunosuppressive signaling of glioma exosomes, and disrupting the positive feedback loop in MSCs with modified Dex could improve PD-1 blockade therapy. ...
5K). Moreover, as expected, the expression levels of FBW7 and IGF2BP2 showed a significant negative correlation in LUAD tissue microarray (Fig. 5L-N). Hence, these results demonstrate that FBW7 negatively regulates the stability of IGF2BP2 protein by ubiquitinating IGF2BP2 in lung cancer ...
IL-33 is a danger signal that binds to its receptor ST2L to promote tumor progression. This study identifies the IL-33/ST2L positive-feedback loop and the trafficking of ST2L membrane presentation in macrophages that contribute to lung tumor progression.
E. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr. Opin. Cell Biol. 14, 140–148 (2002). Article CAS PubMed Google Scholar Lek, M. et al. A homeodomain feedback circuit underlies step-function interpretation of a Shh ...