Several mutations have been described in the CYP2D6 gene that abolish CYP2D6 activity, however, four mutations accounts for the majority of the poor metabolizers. Genomic DNA was etracted from a total of 109 EDTA-supplemented blood samples of patients with dilated cardiomyopathy.Sławomir Smolik...
Many studies have identified the genetic CYP2D6 status as an independent predictor of the outcome of tamoxifen treatment in women with breast cancer, but ... SF Zhou - 《Clinical Pharmacokinetics》 被引量: 1251发表: 2009年 The CYP2D6 poor metabolizer phenotype may be associated with risperidone ...
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen Extensive metabolizers were defined as patients without a *4 allele (i.e., wt/wt) who were not co-prescribed a CYP2D6 inhibitor. Patients with ... MP Goetz,SK Knox,VJ Suman,... - 《Breast Cancer Res ...
poor metabolizer Pharmacology A person who metabolizes a probe drug–the rate of which is related to the metabolizing cytochrome P-450 enzyme–slower than others; a person can be a PM of one probe drug, and an extensive metabolizer of another. See Probe drug. Cf Extensive metabolizer. ...
It is important to note, however, that a requirement or recommendation for pre-emptive testing for CYP2D6 metabolizer status is not included in the drug label. We present two cases of acute dystonia in two non-consanguineous male adolescents: one following metoclopramide and cimetidine administration...
Based on the present and our previous data, the poor metabolizer frequency in Japanese was estimated to be 0.39%, which accounted for approximately 45% of the individuals phenotyped as poor metabolizers by in-vivo tests. 展开 关键词: CYP2D6*3 CYP2D6*4 CYP2D6*5 CYP2D6*18 genotype ...
Additionally, in 60 randomly selected healthy individuals both the CYP2D6 phenotype and genotype was assessed to determine accordance between the methods. RESULTS: Of 300 participants in the study 25 (8.3%) were classified as poor metabolizers, 44 (14.7%) as intermediate metabolizers, and 231 (...
Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-exposure study. et al.Life-threatening dextromethorphan intoxication associated with interaction with amitriptyline in a poor CYP2D6 metabolizer: a single case re-...
CYP2D6 poor metabolizers (PMs) cannot convert hydrocodone to hydromorphone. It is believed that PMs will not gain meaningful analgesia from hydrocodone. Responses of PMs were compared with those of competent metabolizers (non-PMs) during hydrocodone/acetaminophen extended release (HC/APAP CR) ...
Re: no evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluox- etine or nortriptyline. Hum Psychopharmacol 2005; 20:61-62.Gillman PK. Re: no evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with ...