Moreover,IL4I1was found correlated with immune infiltration. Finally, the in vitro experiments revealed the promotion ofIL4I1on cancer cell proliferation, migration and invasion.#The increasedIL4I1expression is
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (for example, those with microsatellite instability). Whether low TMB cancers, which are largely refractory to immunotherapy, harbor potent...
gastric cancertumor-associated macrophagesimmune evasionprognosisadjuvant chemotherapyBackground: Tumor-associated macrophages (TAMs) are prominent immune cells infiltrating in solid tumors with phenotypic and functional heterogeneity. However, tdoi:10.2139/ssrn.3414432Liu, Xin...
However, the function and molecular mechanism ofin non-small cell lung cancer (NSCLC) development are largely unknown. Thus, we studied the correlation betweenmutations and clinico-molecular features in the patients with NSCLC. We reported the frequencies and prognostic values ofmutations in a ...
Although extensive research has been carried out on the carcinogenic effects of MDM4, the role of MDM4 in pan-cancer is still elusive. In this research, we analyzed the correlations between MDM4 expression and prognostic value, immune fea- tures, genetic mutation, or tumor related pathways in...
Tumor metabolic heterogeneity can alter the TME, promoting immune evasion and cancer progression [9, 10]. Increased tumor glycolysis generates a highly acidic microenvironment, influencing the composition of infiltrating immune cells [11]. Glycolytic TME can promote metabolic reprogramming of TAMs, ...
Poor immune recovery has been associated with sex, baseline CD4+ and CD8+ T cell count, and HIV RNA levels, as well as related to altera- tions in T cell phenotype, function, and PD-1 expression. Further, recent reports have demonstrated that various metabolites, such as serine ...
In such cases, ICI can rapidly improve overall condition, a phenomenon known as a Lazarus-type response, as seen in other cancers such as non-small cell lung cancer. 展开 关键词: Performance status Microsatellite instability-high Endometrial cancer Immune checkpoint inhibitor Pembrolizumab ...
PD-1+CD8+ T cells could promote tumor progression by forming an immune escape microenvironment in a variety of malignancies [17], [18]. Previous studies reported that TIGIT+ B cells could affect the function of T cells and then participate in immune regulation [9]. We performed multiplex IF...
Notably, immunotherapy, especially immune checkpoint inhibitors, brings new hope to the treatment of breast cancer [16,17,18,19,20]. Recent studies have indicated that aberrant activation of Rho GTPases relates to the malignant biological behavior of breast cancer cells [21,22,23]. ECT2 (...