Ponazuril kills the coccidia which makes for a faster response to treatment and shorter course of therapy. The problem for dogs and cats is that Ponazuril is manufactured for horses and comes in paste that is impractical for small animal use. The paste c
Ponazuril is a triazinetrione anti-protozoal drug. Other drugs within the triazine group include diclazuril and toltrazuril. Ponazuril is an active metabolite of toltrazuril; the alternate chemical name for ponazuril is toltrazuril sulfone. Ponazuril has broad spectrum activity against coccidia and ...
It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses. View all ...
Effects of coadministration of corn oil and ponazuril on serum and cerebrospinal fluid concentrations of ponazuril in horsesanticoccidialcentral nervous systemequine protozoal myeloencephalitispharmacokineticsPonazuril is used for the treatment of equine protozoal myeloencephalitis (EPM). Coadministration of...
1. Ponazuril is a drug currently approved for the treatment of equine protozoal myeloencephalitis in horses, caused by Sarcocystis neurona.2. Ponazuril have been preparing a formulary version of the medication for use in small animals such as cats and dogs against coccidia, ...
Other horses (5 horses/group) each received 612,500 S neurona sporocysts via nasogastric tube (day 0) and were not treated or were administered ponazuril (20 mg/kg, PO) every 7 days (beginning on day 5) or every 14 days (beginning on day 12) for 12 weeks. Blood and CSF samples ...
Horses persistently infected with B. equi or B. caballi are efficient reservoirs for transmission by Rhipicephalus (Boophilus) microplus (13, 14) and D. nitens respectively (10). As previously reported B. caballi is transovarially transmitted, however without re-exposure of ticks to an infected...