A new supramolecular natural product gel based on pomolic acid (PA) has been reported firstly.The morphology and microrheology of PA-gel were characterized systematically.The self-assembled mechanism of PA-gel was proposed in detail.The self-assembled compounds were considered to affect integrative mec...
We examined the effects of pentacyclic triterpene pomolic acid (PA) on docetaxelresistant PC3 cells. Cell viability was evaluated using the MTT assay. Apoptosis was evaluated by cell cycle analysis using flow cytometry. The activity of multiple drug resistance (MDR) proteins was determined by the ...
Pomolic acid (PA) is a pentacyclic triterpene which has been previously described as active in inhibiting the growth of K562 cell line—originated from chronic myeloid leukemia (CML) in blast crisis—and its vincristine-resistant derivative K562-Lucena1. In this work, cells from CML patients were...
Pomolic acid (PA) isolated from Licania pittieri has hypotensive effects in rats, inhibits human platelet aggregation and elicits endothelium-dependent relaxation in rat aortic rings. The present study was designed to investigate the effects of PA on cardiomyocytes. Trabeculae and enzymatically isolated ...
Pomolic acidEGFAngiogenesisHIF1 alphaVEGFmTORBackground: Pomolic acid (PA), an active triterpenoid from Euscaphis japonica, inhibits the proliferation of a variety of cancer cells, but the molecular mechanisms of the anti-angiogenic potential of PA have not been fully elucidated in breast cancer ...
Pomolic acid also down-modulated the activity of the multidrug resistance associated protein 1 (MRP1) and inhibited migration of GBM cells. These results show that PA acts on several pathways of GBM drug resistance and therefore may be of potential interest for the treatment of this tumor.Lívia...
Park JH, Cho YY, Yoon SW and Park B: Suppression of MMP-9 and FAK expression by pomolic acid via blocking of NF-κB/ ERK/mTOR signaling pathways in growth factor-stimulated human breast cancer cells. Int J Oncol 49: 1230-1240, 2016....
Pomolic acid-28-O-β-D-glucopyranoseBACKGROUND Colon cancer remains a leading cause of death globally.Pomolic acid(PA)can be separated from the ethyl acetate fraction of achyrocline satureioides.AIM To determine the effects of PA and its glucopyranose ester,pomolic acid-28-O-尾-D-...
Pomolic acid (3-beta,19alpha-Dihydroxy-urs-12-en-28-oic acid, PA) is a naturally occurring pentacyclic triterpenoid. Derived from the mevalonate pathway through cyclization of 2,3-oxidosqualene, it has been widely found in several plant species. In the mid-1960s, PA was identified as the ...
Background: Pomolic acid (PA), an active triterpenoid from Euscaphis japonica, inhibits the proliferation of a variety of cancer cells, but the molecular mechanisms of the anti-angiogenic potential of PA have not been fully elucidated in breast cancer cells. Hypothesis/purpose: We investigated the...